Comparative analysis of ceftriaxone, cefotaxime and amikacin empirical use in secondary widespread peritonitis in the age aspect
Background. A significant threat to the children health is posed by widespread forms of secondary peritonitis, which account for 16.8-42.88% of cases, and the postoperative complications frequency reaches 4%. The purpose of the study was to evaluate the empirical use effecacy of ceftriaxone, cefo...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penza State University Publishing House
2024-11-01
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| Series: | Известия высших учебных заведений. Поволжский регион: Медицинские науки |
| Subjects: | |
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| Summary: | Background. A significant threat to the children health is posed by widespread
forms of secondary peritonitis, which account for 16.8-42.88% of cases, and the postoperative
complications frequency reaches 4%. The purpose of the study was to evaluate the empirical
use effecacy of ceftriaxone, cefotaxime and amikacin in different age children with
secondary widespread peritonitis. Materials and methods. In 63 children (44.4%) of different
age groups with secondary widespread peritonitis, the dynamics of changes in inflammatory
markers before surgery and in the early postoperative period were assessed, and a
bacteriological examination of the abdominal cavity contents was carried out to identify the
microflora sensitivity to ceftriaxone, cefotaxime and amikacin. Results. A conducted study
of children with secondary widespread peritonitis demonstrated its highest incidence at an
early age. The maximum content of inflammatory markers was determined before surgery
and 1 day after surgery in all patients without exception. At the same time, at younger age
groups of patients, the increase in these indicators occurred to a greater extent, and their
normalization was slower, that indicated a more severe course of the purulent-inflammatory
process in the abdominal cavity. Bacteriological examination of the abdominal cavity contents
demonstrated the most common occurrence of E. coli (38%) both as a monovalent culture
and in association with other pathogenic microorganisms. The most effective antibacterial
drug was amikacin (88.2%). Ceftriaxone (79.4%) and cefotaxime (82.4%) showed less
antimicrobial effect. The sensitivity lack of the microorganisms association to prescribed
antibiotics was the reason for the abdominal abscesses development in 2 children in the
postoperative period. Conclusion. Empirical antibacterial therapy plays an important role in
the treatment of secondary widespread peritonitis. The use of amikacin as a starting antibiotic
promotes the most effective effect on pathogenic microflora in secondary widespread
peritonitis. |
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| ISSN: | 2072-3032 |