Dephosphorylated uncarboxylated Matrix-Gla-Protein as candidate biomarker for immune-mediated vascular remodeling and prognosis in pulmonary hypertension

Dephosphorylated uncarboxylated Matrix-Gla-Protein as candidate biomarker for immune-mediated vascular remodeling and prognosis in pulmonary hypertension

Abstract Pulmonary arterial hypertension (PAH) is a disease characterized by pulmonary vascular remodeling. Since dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP) is associated with cardiovascular mortality in systemic sclerosis, a disease associated with PAH, and immune-system involvem...

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Bibliographic Details
Main Authors: R. Tobal, J. Potjewijd, F. de Vries, D. P.C. van Doorn, A. Jaminon, R. Bittner, C. Akbulut, V. van Empel, P. Heeringa, J. Damoiseaux, L. Schurgers, P. van Paassen
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Pulmonary hypertension
Vascular remodeling
Dp-ucMGP
Inflammation
Immune checkpoint proteins
Biomarkers
Online Access:https://doi.org/10.1038/s41598-024-77000-w
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