Pleiotropic tumor suppressive functions of PTEN missense mutations during gliomagenesis

Pleiotropic tumor suppressive functions of PTEN missense mutations during gliomagenesis

Summary: PTEN plays a crucial role in preventing the development of glioblastoma (GBM), a severe and untreatable brain cancer. In GBM, most PTEN deficiencies are missense mutations that have not been thoroughly examined. Here, we leveraged genetically modified mice and isogenic astrocyte cell cultur...

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Bibliographic Details
Main Authors: Hyun Jung Jun, Joao A. Paulo, Victoria A. Appleman, Tomer M. Yaron-Barir, Jared L. Johnson, Alan T. Yeo, Vaughn A. Rogers, Shan Kuang, Hemant Varma, Steven P. Gygi, Lloyd C. Trotman, Al Charest
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224025033
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http://www.sciencedirect.com/science/article/pii/S2589004224025033

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