ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells
Homeobox genes play an important role in health and disease including oncogenesis. The present investigation aimed to study ERN1-dependent hypoxic regulation of the expression of genes encoding homeobox proteins MEIS (zinc finger E-box binding homeobox 2) and LIM homeobox 1 family, SPAG4 (sperm asso...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2024-01-01
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| Series: | Endocrine Regulations |
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| Online Access: | https://doi.org/10.2478/enr-2024-0006 |
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| author | Krasnytska Daria A. Khita Olena O. Viletska Yuliia M. Minchenko Dmytro O. Halkin Oleh V. Rudnytska Olha V. Hoian Sofiia L. Minchenko Oleksandr H. |
| author_facet | Krasnytska Daria A. Khita Olena O. Viletska Yuliia M. Minchenko Dmytro O. Halkin Oleh V. Rudnytska Olha V. Hoian Sofiia L. Minchenko Oleksandr H. |
| author_sort | Krasnytska Daria A. |
| collection | DOAJ |
| description | Homeobox genes play an important role in health and disease including oncogenesis. The present investigation aimed to study ERN1-dependent hypoxic regulation of the expression of genes encoding homeobox proteins MEIS (zinc finger E-box binding homeobox 2) and LIM homeobox 1 family, SPAG4 (sperm associated antigen 4) and NKX3-1 (NK3 homeobox 1) in U87MG glioblastoma cells in response to inhibition of ERN1 (endoplasmic reticulum to nucleus signaling 1) for evaluation of their possible significance in the control of glioblastoma growth. |
| format | Article |
| id | doaj-art-f7aa9d84f6224def9fd6df5e506bf5f0 |
| institution | Kabale University |
| issn | 1336-0329 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Endocrine Regulations |
| spelling | doaj-art-f7aa9d84f6224def9fd6df5e506bf5f02024-11-25T11:20:07ZengSciendoEndocrine Regulations1336-03292024-01-01581475610.2478/enr-2024-0006ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cellsKrasnytska Daria A.0Khita Olena O.1Viletska Yuliia M.2Minchenko Dmytro O.3Halkin Oleh V.4Rudnytska Olha V.5Hoian Sofiia L.6Minchenko Oleksandr H.7Department of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, UkraineDepartment of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, UkraineDepartment of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, UkraineDepartment of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, UkraineDepartment of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, UkraineDepartment of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, UkraineDepartment of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, UkraineDepartment of Molecular Biology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, UkraineHomeobox genes play an important role in health and disease including oncogenesis. The present investigation aimed to study ERN1-dependent hypoxic regulation of the expression of genes encoding homeobox proteins MEIS (zinc finger E-box binding homeobox 2) and LIM homeobox 1 family, SPAG4 (sperm associated antigen 4) and NKX3-1 (NK3 homeobox 1) in U87MG glioblastoma cells in response to inhibition of ERN1 (endoplasmic reticulum to nucleus signaling 1) for evaluation of their possible significance in the control of glioblastoma growth.https://doi.org/10.2478/enr-2024-0006u87mg glioblastoma cellsern1 knockdownhypoxiahomeobox genesmrna expression |
| spellingShingle | Krasnytska Daria A. Khita Olena O. Viletska Yuliia M. Minchenko Dmytro O. Halkin Oleh V. Rudnytska Olha V. Hoian Sofiia L. Minchenko Oleksandr H. ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells Endocrine Regulations u87mg glioblastoma cells ern1 knockdown hypoxia homeobox genes mrna expression |
| title | ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells |
| title_full | ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells |
| title_fullStr | ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells |
| title_full_unstemmed | ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells |
| title_short | ERN1 knockdown modifies the hypoxic regulation of homeobox gene expression in U87MG glioblastoma cells |
| title_sort | ern1 knockdown modifies the hypoxic regulation of homeobox gene expression in u87mg glioblastoma cells |
| topic | u87mg glioblastoma cells ern1 knockdown hypoxia homeobox genes mrna expression |
| url | https://doi.org/10.2478/enr-2024-0006 |
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