Organoids as Tools for Investigating Skin Aging: Mechanisms, Applications, and Insights
Organoids have emerged as transformative tools in biomedical research, renowned for their ability to replicate the complexity construct of human tissues. Skin aging is a multifaceted biological process, influenced by both intrinsic factors and extrinsic factors. Traditional models for studying skin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/11/1436 |
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| author | Xin-Yu Wang Qian-Nan Jia Jun Li He-Yi Zheng |
| author_facet | Xin-Yu Wang Qian-Nan Jia Jun Li He-Yi Zheng |
| author_sort | Xin-Yu Wang |
| collection | DOAJ |
| description | Organoids have emerged as transformative tools in biomedical research, renowned for their ability to replicate the complexity construct of human tissues. Skin aging is a multifaceted biological process, influenced by both intrinsic factors and extrinsic factors. Traditional models for studying skin aging often fall short in capturing the intricate dynamics of human skin. In contrast, skin organoids offer a more physiologically relevant system, reflecting the structural and functional characteristics of native skin. These characteristics make skin organoids highly suitable for studying the mechanisms of skin aging, identifying novel therapeutic targets, and testing anti-aging interventions. Despite their promise, challenges such as limited scalability, reproducibility, and ethical considerations remain. Addressing these hurdles through interdisciplinary research and technological advancements will be essential to maximizing the potential of skin organoids for dermatological research and personalized anti-aging therapies. |
| format | Article |
| id | doaj-art-f7aa41cba60e4c6abc075b75db68501f |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-f7aa41cba60e4c6abc075b75db68501f2024-11-26T17:54:18ZengMDPI AGBiomolecules2218-273X2024-11-011411143610.3390/biom14111436Organoids as Tools for Investigating Skin Aging: Mechanisms, Applications, and InsightsXin-Yu Wang0Qian-Nan Jia1Jun Li2He-Yi Zheng3Peking Union Medical College Hospital (Dongdan Campus), No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, ChinaPeking Union Medical College Hospital (Dongdan Campus), No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, ChinaPeking Union Medical College Hospital (Dongdan Campus), No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, ChinaPeking Union Medical College Hospital (Dongdan Campus), No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing 100730, ChinaOrganoids have emerged as transformative tools in biomedical research, renowned for their ability to replicate the complexity construct of human tissues. Skin aging is a multifaceted biological process, influenced by both intrinsic factors and extrinsic factors. Traditional models for studying skin aging often fall short in capturing the intricate dynamics of human skin. In contrast, skin organoids offer a more physiologically relevant system, reflecting the structural and functional characteristics of native skin. These characteristics make skin organoids highly suitable for studying the mechanisms of skin aging, identifying novel therapeutic targets, and testing anti-aging interventions. Despite their promise, challenges such as limited scalability, reproducibility, and ethical considerations remain. Addressing these hurdles through interdisciplinary research and technological advancements will be essential to maximizing the potential of skin organoids for dermatological research and personalized anti-aging therapies.https://www.mdpi.com/2218-273X/14/11/1436skin agingaging skin equivalentin vitro skin modelsskin organoidaging skin organoid |
| spellingShingle | Xin-Yu Wang Qian-Nan Jia Jun Li He-Yi Zheng Organoids as Tools for Investigating Skin Aging: Mechanisms, Applications, and Insights Biomolecules skin aging aging skin equivalent in vitro skin models skin organoid aging skin organoid |
| title | Organoids as Tools for Investigating Skin Aging: Mechanisms, Applications, and Insights |
| title_full | Organoids as Tools for Investigating Skin Aging: Mechanisms, Applications, and Insights |
| title_fullStr | Organoids as Tools for Investigating Skin Aging: Mechanisms, Applications, and Insights |
| title_full_unstemmed | Organoids as Tools for Investigating Skin Aging: Mechanisms, Applications, and Insights |
| title_short | Organoids as Tools for Investigating Skin Aging: Mechanisms, Applications, and Insights |
| title_sort | organoids as tools for investigating skin aging mechanisms applications and insights |
| topic | skin aging aging skin equivalent in vitro skin models skin organoid aging skin organoid |
| url | https://www.mdpi.com/2218-273X/14/11/1436 |
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