Adiponectin-receptor agonism prevents right ventricular tissue pathology in a mouse model of Duchenne muscular dystrophy

Adiponectin-receptor agonism prevents right ventricular tissue pathology in a mouse model of Duchenne muscular dystrophy

Objective: Cardiac fibrosis during Duchenne muscular dystrophy (DMD) arises from cellular damage and inflammation and is associated with metabolic dysfunction. The extent to which these relationships develop across all 4 cardiac chambers, particularly during early-stage disease, remains unknown. Met...

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Bibliographic Details
Main Authors: Shivam Gandhi, Luca J. Delfinis, Parashar D. Bhatt, Madison C. Garibotti, Catherine A. Bellissimo, Amireza N. Goli, Brooke A. Morris, Aditya N. Brahmbhatt, Simona Yakobov-Shimonov, Fasih A. Rahman, Joe Quadrilatero, Jeremy A. Simpson, Gary Sweeney, Ali A. Abdul-Sater, Peter H. Backx, Henry H. Hsu, Christopher G.R. Perry
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Metabolism
Subjects:
Cardiomyopathy
Inflammation
Mitochondria
Duchenne muscular dystrophy
Fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000869
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