Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic stroke
PANoptosis is a novelly defined mode of programmed cell death that involves the activation of multiple cellular death pathways, including pyroptosis, apoptosis, and necroptosis, triggering robust inflammatory reactions. Autophagy is a crucial cellular process that maintains cellular homeostasis and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2024.1482015/full |
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| author | He-Yan Tian Yun-Xing Lei Jing-Tao Zhou Long-Jun Liu Tong Yang Yue Zhou Jin-Wen Ge Jin-Wen Ge Chen Xu Zhi-Gang Mei |
| author_facet | He-Yan Tian Yun-Xing Lei Jing-Tao Zhou Long-Jun Liu Tong Yang Yue Zhou Jin-Wen Ge Jin-Wen Ge Chen Xu Zhi-Gang Mei |
| author_sort | He-Yan Tian |
| collection | DOAJ |
| description | PANoptosis is a novelly defined mode of programmed cell death that involves the activation of multiple cellular death pathways, including pyroptosis, apoptosis, and necroptosis, triggering robust inflammatory reactions. Autophagy is a crucial cellular process that maintains cellular homeostasis and protects cells from various stresses. PANoptosis and autophagy, both vital players in the intricate pathological progression of ischemic stroke (IS), a brain ailment governed by intricate cell death cascades, have garnered attention in recent years for their potential interplay. While mounting evidence hints at a crosstalk between these two processes in IS, the underlying mechanisms remain elusive. Therefore, this review delves into and dissects the intricate mechanisms that underpin the intersection of PANoptosis and autophagy in this devastating condition. In conclusion, the crosstalk between PANoptosis and autophagy in IS presents a promising target for the development of novel stroke therapies. Understanding the interplay between these two pathways offers a much-needed insight into the underlying mechanisms of IS and opens the possibility for new therapeutic strategies. |
| format | Article |
| id | doaj-art-f7a264821dd44494a76d5f5be699d0ef |
| institution | Kabale University |
| issn | 1662-5099 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj-art-f7a264821dd44494a76d5f5be699d0ef2025-01-08T06:12:01ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992025-01-011710.3389/fnmol.2024.14820151482015Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic strokeHe-Yan Tian0Yun-Xing Lei1Jing-Tao Zhou2Long-Jun Liu3Tong Yang4Yue Zhou5Jin-Wen Ge6Jin-Wen Ge7Chen Xu8Zhi-Gang Mei9School of Medical Technology and Nursing, Shenzhen Polytechnic University, Shenzhen, ChinaSchool of Medical Technology and Nursing, Shenzhen Polytechnic University, Shenzhen, ChinaSchool of Medical Technology and Nursing, Shenzhen Polytechnic University, Shenzhen, ChinaSchool of Medical Technology and Nursing, Shenzhen Polytechnic University, Shenzhen, ChinaKey Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, ChinaKey Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, ChinaKey Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, ChinaHunan Academy of Traditional Chinese Medicine, Changsha, ChinaSchool of Medical Technology and Nursing, Shenzhen Polytechnic University, Shenzhen, ChinaKey Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, ChinaPANoptosis is a novelly defined mode of programmed cell death that involves the activation of multiple cellular death pathways, including pyroptosis, apoptosis, and necroptosis, triggering robust inflammatory reactions. Autophagy is a crucial cellular process that maintains cellular homeostasis and protects cells from various stresses. PANoptosis and autophagy, both vital players in the intricate pathological progression of ischemic stroke (IS), a brain ailment governed by intricate cell death cascades, have garnered attention in recent years for their potential interplay. While mounting evidence hints at a crosstalk between these two processes in IS, the underlying mechanisms remain elusive. Therefore, this review delves into and dissects the intricate mechanisms that underpin the intersection of PANoptosis and autophagy in this devastating condition. In conclusion, the crosstalk between PANoptosis and autophagy in IS presents a promising target for the development of novel stroke therapies. Understanding the interplay between these two pathways offers a much-needed insight into the underlying mechanisms of IS and opens the possibility for new therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fnmol.2024.1482015/fullischemic strokePANoptosisautophagypyroptosisapoptosisnecroptosis |
| spellingShingle | He-Yan Tian Yun-Xing Lei Jing-Tao Zhou Long-Jun Liu Tong Yang Yue Zhou Jin-Wen Ge Jin-Wen Ge Chen Xu Zhi-Gang Mei Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic stroke Frontiers in Molecular Neuroscience ischemic stroke PANoptosis autophagy pyroptosis apoptosis necroptosis |
| title | Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic stroke |
| title_full | Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic stroke |
| title_fullStr | Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic stroke |
| title_full_unstemmed | Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic stroke |
| title_short | Insight into interplay between PANoptosis and autophagy: novel therapeutics in ischemic stroke |
| title_sort | insight into interplay between panoptosis and autophagy novel therapeutics in ischemic stroke |
| topic | ischemic stroke PANoptosis autophagy pyroptosis apoptosis necroptosis |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2024.1482015/full |
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