Association between phase angle and daily creatinine excretion changes in critically ill patients: an approach to muscle mass
Assessing muscle mass in critically ill patients remains challenging. This retrospective cohort study explores the potential of phase angle (PA°) derived from bioelectrical impedance analysis (BIA) as a surrogate marker for muscle mass monitoring by associating it with daily creatinine excretion (DC...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1508709/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841556835659677696 |
|---|---|
| author | Patricio Vargas-Errázuriz Patricio Vargas-Errázuriz Natalia Dreyse Natalia Dreyse Natalia Dreyse René López René López Marcelo Cano-Cappellacci Jerónimo Graf Julia Guerrero Julia Guerrero |
| author_facet | Patricio Vargas-Errázuriz Patricio Vargas-Errázuriz Natalia Dreyse Natalia Dreyse Natalia Dreyse René López René López Marcelo Cano-Cappellacci Jerónimo Graf Julia Guerrero Julia Guerrero |
| author_sort | Patricio Vargas-Errázuriz |
| collection | DOAJ |
| description | Assessing muscle mass in critically ill patients remains challenging. This retrospective cohort study explores the potential of phase angle (PA°) derived from bioelectrical impedance analysis (BIA) as a surrogate marker for muscle mass monitoring by associating it with daily creatinine excretion (DCE), a structural and metabolic muscle mass marker. In 20 ICU patients, we observed a linear relationship between PA° and DCE at initial (S1) and follow-up (S2) points, with Rho values of 0.78 and 0.65, respectively, as well as between their percentage changes (Rho = 0.80). Multivariate analysis confirmed a strong association between changes in PA° and DCE (adjusted R2 of 0.73), while changes in the extracellular water to total body water (ECW/TBW) ratio showed no significant association. This study establishes a relationship between a BIA-derived independent-weight parameter and DCE, highlighting the potential of PA° for muscle mass monitoring during acute changes, such as those seen in ICU settings. Integrating PA° into clinical practice could provide a non-invasive and reliable tool to enhance muscle assessment and support targeted interventions in critically ill patients. |
| format | Article |
| id | doaj-art-f795d3a41f0c46c7b3be349b7a83b120 |
| institution | Kabale University |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-f795d3a41f0c46c7b3be349b7a83b1202025-01-07T06:40:22ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-01-011510.3389/fphys.2024.15087091508709Association between phase angle and daily creatinine excretion changes in critically ill patients: an approach to muscle massPatricio Vargas-Errázuriz0Patricio Vargas-Errázuriz1Natalia Dreyse2Natalia Dreyse3Natalia Dreyse4René López5René López6Marcelo Cano-Cappellacci7Jerónimo Graf8Julia Guerrero9Julia Guerrero10Grupo Intensivo, Instituto de Ciencias e Innovación en Medicina (ICIM), Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago, ChileDepartamento de Paciente Crítico, Clínica Alemana de Santiago, Santiago, ChileGrupo Intensivo, Instituto de Ciencias e Innovación en Medicina (ICIM), Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago, ChileDepartamento de Paciente Crítico, Clínica Alemana de Santiago, Santiago, ChileDepartamento de Farmacia, Clínica Alemana de Santiago, Santiago, ChileGrupo Intensivo, Instituto de Ciencias e Innovación en Medicina (ICIM), Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago, ChileDepartamento de Paciente Crítico, Clínica Alemana de Santiago, Santiago, ChilePhysical Exercise Sciences Laboratory, Physical Therapy Department, University of Chile, Santiago, ChileDepartamento de Paciente Crítico, Clínica Alemana de Santiago, Santiago, ChileDepartamento de Paciente Crítico, Clínica Alemana de Santiago, Santiago, ChileDisciplinary Program of Physiology and Biophysics, Institute of Biomedical Sciences, Medicine Faculty, University of Chile, Santiago, ChileAssessing muscle mass in critically ill patients remains challenging. This retrospective cohort study explores the potential of phase angle (PA°) derived from bioelectrical impedance analysis (BIA) as a surrogate marker for muscle mass monitoring by associating it with daily creatinine excretion (DCE), a structural and metabolic muscle mass marker. In 20 ICU patients, we observed a linear relationship between PA° and DCE at initial (S1) and follow-up (S2) points, with Rho values of 0.78 and 0.65, respectively, as well as between their percentage changes (Rho = 0.80). Multivariate analysis confirmed a strong association between changes in PA° and DCE (adjusted R2 of 0.73), while changes in the extracellular water to total body water (ECW/TBW) ratio showed no significant association. This study establishes a relationship between a BIA-derived independent-weight parameter and DCE, highlighting the potential of PA° for muscle mass monitoring during acute changes, such as those seen in ICU settings. Integrating PA° into clinical practice could provide a non-invasive and reliable tool to enhance muscle assessment and support targeted interventions in critically ill patients.https://www.frontiersin.org/articles/10.3389/fphys.2024.1508709/fullphase angledaily creatinine excretioncritical caremuscle massbioelectrical impedance analysis |
| spellingShingle | Patricio Vargas-Errázuriz Patricio Vargas-Errázuriz Natalia Dreyse Natalia Dreyse Natalia Dreyse René López René López Marcelo Cano-Cappellacci Jerónimo Graf Julia Guerrero Julia Guerrero Association between phase angle and daily creatinine excretion changes in critically ill patients: an approach to muscle mass Frontiers in Physiology phase angle daily creatinine excretion critical care muscle mass bioelectrical impedance analysis |
| title | Association between phase angle and daily creatinine excretion changes in critically ill patients: an approach to muscle mass |
| title_full | Association between phase angle and daily creatinine excretion changes in critically ill patients: an approach to muscle mass |
| title_fullStr | Association between phase angle and daily creatinine excretion changes in critically ill patients: an approach to muscle mass |
| title_full_unstemmed | Association between phase angle and daily creatinine excretion changes in critically ill patients: an approach to muscle mass |
| title_short | Association between phase angle and daily creatinine excretion changes in critically ill patients: an approach to muscle mass |
| title_sort | association between phase angle and daily creatinine excretion changes in critically ill patients an approach to muscle mass |
| topic | phase angle daily creatinine excretion critical care muscle mass bioelectrical impedance analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1508709/full |
| work_keys_str_mv | AT patriciovargaserrazuriz associationbetweenphaseangleanddailycreatinineexcretionchangesincriticallyillpatientsanapproachtomusclemass AT patriciovargaserrazuriz associationbetweenphaseangleanddailycreatinineexcretionchangesincriticallyillpatientsanapproachtomusclemass AT nataliadreyse associationbetweenphaseangleanddailycreatinineexcretionchangesincriticallyillpatientsanapproachtomusclemass AT nataliadreyse associationbetweenphaseangleanddailycreatinineexcretionchangesincriticallyillpatientsanapproachtomusclemass AT nataliadreyse associationbetweenphaseangleanddailycreatinineexcretionchangesincriticallyillpatientsanapproachtomusclemass AT renelopez associationbetweenphaseangleanddailycreatinineexcretionchangesincriticallyillpatientsanapproachtomusclemass AT renelopez associationbetweenphaseangleanddailycreatinineexcretionchangesincriticallyillpatientsanapproachtomusclemass AT marcelocanocappellacci associationbetweenphaseangleanddailycreatinineexcretionchangesincriticallyillpatientsanapproachtomusclemass AT jeronimograf associationbetweenphaseangleanddailycreatinineexcretionchangesincriticallyillpatientsanapproachtomusclemass AT juliaguerrero associationbetweenphaseangleanddailycreatinineexcretionchangesincriticallyillpatientsanapproachtomusclemass AT juliaguerrero associationbetweenphaseangleanddailycreatinineexcretionchangesincriticallyillpatientsanapproachtomusclemass |