Risk factors for delayed gastric emptying after pancreatoduodenectomy: a 10-year retrospective study
Background Delayed gastric emptying (DGE) is a frequent complication of pancreatoduodenectomy (PD) and is associated with prolonged hospital stay, readmission, increased hospital costs and decreased quality of life. However, the pathophysiology of DGE remains unclear.Methods This is a retrospective...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2453076 |
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| author | Carlos Jiménez-Romero Agustín de Juan Lerma Alberto Marcacuzco Quinto Oscar Caso Maestro Laura Alonso Murillo Paula Rioja Conde Iago Justo Alonso |
| author_facet | Carlos Jiménez-Romero Agustín de Juan Lerma Alberto Marcacuzco Quinto Oscar Caso Maestro Laura Alonso Murillo Paula Rioja Conde Iago Justo Alonso |
| author_sort | Carlos Jiménez-Romero |
| collection | DOAJ |
| description | Background Delayed gastric emptying (DGE) is a frequent complication of pancreatoduodenectomy (PD) and is associated with prolonged hospital stay, readmission, increased hospital costs and decreased quality of life. However, the pathophysiology of DGE remains unclear.Methods This is a retrospective study of patients who underwent PD for pancreatic or periampullary tumours. All these patients were operated between January 2012 and February 2023. The patients were divided into four groups according to the development of DGE after PD: No DGE, DGE grade A, DGE grade B and DGE grade C. The groups were compared in terms of outcomes and complications. We also analysed the preoperative and perioperative risk factors for DGE development.Results Between January 2012 and February 2023, a total of 250 patients underwent PD. These patients were divided into four groups: No DGE (n = 152); DGE grade A (n = 42); DGE grade B (n = 45); and DGE grade C (n = 11). The incidence of the postoperative pancreatic fistulas (POPFs) grade B/C was significantly higher in the DGE grade C group (p < .001), and the rates of post-pancreatectomy haemorrhage (p = .004) and reoperation (p < .001) were significantly higher in the DGE grade B/C groups. A significantly higher rate of grade III–IV Clavien–Dindo complications (p < .001), longer intensive care unit (p < .001) and longer hospital stays (p < .001) were observed in the DGE grade C group; and 90-day mortality (p < .001) and morbidity (p < .001) were significantly higher in the DGE grade B/C groups. Multivariate analysis demonstrated that the POPF grade B/C was a risk factor of DGE grade B/C (OR: 9.147; 95%CI: 4.125–20.281; p < .001).Conclusions POPF B/C is a risk factor for grade B/C DGE. Prevention of surgical complications and early treatment could contribute to the decreased incidence of DGE. |
| format | Article |
| id | doaj-art-f774e9dd7f7a4441972d263880c1b0e0 |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
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| series | Annals of Medicine |
| spelling | doaj-art-f774e9dd7f7a4441972d263880c1b0e02025-01-16T12:04:30ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2453076Risk factors for delayed gastric emptying after pancreatoduodenectomy: a 10-year retrospective studyCarlos Jiménez-Romero0Agustín de Juan Lerma1Alberto Marcacuzco Quinto2Oscar Caso Maestro3Laura Alonso Murillo4Paula Rioja Conde5Iago Justo Alonso6Department of Surgery, Faculty of Medicine, Unit of Hepato-Pancreato-Biliary Surgery and Abdominal Organ Transplantation, Doce de Octubre University Hospital, Instituto de Investigación (imas12), Complutense University, Madrid, SpainDepartment of Surgery, Faculty of Medicine, Unit of Hepato-Pancreato-Biliary Surgery and Abdominal Organ Transplantation, Doce de Octubre University Hospital, Instituto de Investigación (imas12), Complutense University, Madrid, SpainDepartment of Surgery, Faculty of Medicine, Unit of Hepato-Pancreato-Biliary Surgery and Abdominal Organ Transplantation, Doce de Octubre University Hospital, Instituto de Investigación (imas12), Complutense University, Madrid, SpainDepartment of Surgery, Faculty of Medicine, Unit of Hepato-Pancreato-Biliary Surgery and Abdominal Organ Transplantation, Doce de Octubre University Hospital, Instituto de Investigación (imas12), Complutense University, Madrid, SpainDepartment of Surgery, Faculty of Medicine, Unit of Hepato-Pancreato-Biliary Surgery and Abdominal Organ Transplantation, Doce de Octubre University Hospital, Instituto de Investigación (imas12), Complutense University, Madrid, SpainDepartment of Surgery, Faculty of Medicine, Unit of Hepato-Pancreato-Biliary Surgery and Abdominal Organ Transplantation, Doce de Octubre University Hospital, Instituto de Investigación (imas12), Complutense University, Madrid, SpainDepartment of Surgery, Faculty of Medicine, Unit of Hepato-Pancreato-Biliary Surgery and Abdominal Organ Transplantation, Doce de Octubre University Hospital, Instituto de Investigación (imas12), Complutense University, Madrid, SpainBackground Delayed gastric emptying (DGE) is a frequent complication of pancreatoduodenectomy (PD) and is associated with prolonged hospital stay, readmission, increased hospital costs and decreased quality of life. However, the pathophysiology of DGE remains unclear.Methods This is a retrospective study of patients who underwent PD for pancreatic or periampullary tumours. All these patients were operated between January 2012 and February 2023. The patients were divided into four groups according to the development of DGE after PD: No DGE, DGE grade A, DGE grade B and DGE grade C. The groups were compared in terms of outcomes and complications. We also analysed the preoperative and perioperative risk factors for DGE development.Results Between January 2012 and February 2023, a total of 250 patients underwent PD. These patients were divided into four groups: No DGE (n = 152); DGE grade A (n = 42); DGE grade B (n = 45); and DGE grade C (n = 11). The incidence of the postoperative pancreatic fistulas (POPFs) grade B/C was significantly higher in the DGE grade C group (p < .001), and the rates of post-pancreatectomy haemorrhage (p = .004) and reoperation (p < .001) were significantly higher in the DGE grade B/C groups. A significantly higher rate of grade III–IV Clavien–Dindo complications (p < .001), longer intensive care unit (p < .001) and longer hospital stays (p < .001) were observed in the DGE grade C group; and 90-day mortality (p < .001) and morbidity (p < .001) were significantly higher in the DGE grade B/C groups. Multivariate analysis demonstrated that the POPF grade B/C was a risk factor of DGE grade B/C (OR: 9.147; 95%CI: 4.125–20.281; p < .001).Conclusions POPF B/C is a risk factor for grade B/C DGE. Prevention of surgical complications and early treatment could contribute to the decreased incidence of DGE.https://www.tandfonline.com/doi/10.1080/07853890.2025.2453076Pancreatoduodenectomydelayed gastric emptyingpost-pancreatoduodenectomy complications |
| spellingShingle | Carlos Jiménez-Romero Agustín de Juan Lerma Alberto Marcacuzco Quinto Oscar Caso Maestro Laura Alonso Murillo Paula Rioja Conde Iago Justo Alonso Risk factors for delayed gastric emptying after pancreatoduodenectomy: a 10-year retrospective study Annals of Medicine Pancreatoduodenectomy delayed gastric emptying post-pancreatoduodenectomy complications |
| title | Risk factors for delayed gastric emptying after pancreatoduodenectomy: a 10-year retrospective study |
| title_full | Risk factors for delayed gastric emptying after pancreatoduodenectomy: a 10-year retrospective study |
| title_fullStr | Risk factors for delayed gastric emptying after pancreatoduodenectomy: a 10-year retrospective study |
| title_full_unstemmed | Risk factors for delayed gastric emptying after pancreatoduodenectomy: a 10-year retrospective study |
| title_short | Risk factors for delayed gastric emptying after pancreatoduodenectomy: a 10-year retrospective study |
| title_sort | risk factors for delayed gastric emptying after pancreatoduodenectomy a 10 year retrospective study |
| topic | Pancreatoduodenectomy delayed gastric emptying post-pancreatoduodenectomy complications |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2453076 |
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