Tet3-mediated DNA demethylation is essential for maintaining the dedifferentiation capacity of mammalian Müller glia

Tet3-mediated DNA demethylation is essential for maintaining the dedifferentiation capacity of mammalian Müller glia

Müller glia (MG) are retinal resident cells with diverse functions, including reprograming and regeneration in certain species. While the mammalian retina possesses molecular mechanisms for MG dedifferentiation and neuronal differentiation, it fails to generate neural progenitors in vivo. We previou...

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Bibliographic Details
Main Authors: Erick J. Martinez-Colin, Ivonne Lezama, Lenin D. Ochoa-de la Paz, Monica Lamas
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
retina
Müller glia
epigenetics
dedifferentiation
neuronal differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2025.1628860/full
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