Improvement of Monacolin K and Pigment Production in <i>Monascus</i> by 5-Azacytidine
<i>Monascus</i> species are known to produce various secondary metabolites with polyketide structures, including Monacolins, pigments, and citrinin. This study investigates the effects of 5-azacytidine on <i>Monascus</i> M1 and RP2. The dry weight, red, yellow, and orange pig...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/10/12/819 |
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| Summary: | <i>Monascus</i> species are known to produce various secondary metabolites with polyketide structures, including Monacolins, pigments, and citrinin. This study investigates the effects of 5-azacytidine on <i>Monascus</i> M1 and RP2. The dry weight, red, yellow, and orange pigment values, and Monacolin K yield of both <i>Monascus</i> strains were measured, and their hyphae observed through electron microscopy. The experimental group showed higher dry weights and pigment values than the control group for both strains. However, Monacolin K production increased substantially only for <i>Monascus</i> M1. Electron micrographs revealed surface wrinkles and large protrusions in both strains after 5-azacytidine treatment. As a potent DNA methylation-promoting agent, 5-azacytidine is very useful for epigenetic and cancer biology studies and for studying secondary metabolism in fungi. |
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| ISSN: | 2309-608X |