SARS-CoV-2 exploits steroidogenic machinery, triggers lipid metabolism for viral replication and induces immune response in Leydig cells of K18-hACE2 mice

SARS-CoV-2 exploits steroidogenic machinery, triggers lipid metabolism for viral replication and induces immune response in Leydig cells of K18-hACE2 mice

BackgroundDuring COVID-19 pandemic, men had reduced serum testosterone and higher mortality rate than women. Variations in high density lipoprotein (HDL) levels were detected in severe COVID-19 individuals. We evaluated the response of testicular macrophages, steroidogenic activity and lipid metabol...

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Bibliographic Details
Main Authors: Salmo Azambuja de Oliveira, André Acácio Souza da Silva, Barry T. Hinton, Giovanni Freitas Gomes, Thiago Mattar Cunha, Paulo Sérgio Cerri, Estela Sasso-Cerri
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
COVID-19
testosterone
cholesterol
lipogenesis
nucleocapsid
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1538461/full
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