Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127− T-Cells in Children with Long-Lasting Type 1 Diabetes

Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127− T-Cells in Children with Long-Lasting Type 1 Diabetes

Pathobiology of type 1 diabetes (T1D) is predominantly associated with T-cell-related actions. Homeostasis of majority of T-cells is critically dependent on signals mediated by CD127 (interleukin-7 receptor, IL-7R). In contrast, regulatory T-cells express very little CD127 and thereby may be delinea...

Full description

Saved in:
Bibliographic Details
Main Authors: Marcin Moniuszko, Barbara Glowinska-Olszewska, Malgorzata Rusak, Marta Jeznach, Kamil Grubczak, Danuta Lipinska, Robert Milewski, Anna Justyna Milewska, Milena Dabrowska, Ewa Jablonska, Adam Kretowski, Maria Gorska, Anna Bodzenta-Lukaszyk, Artur Bossowski
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2013/459210
Tags: Add Tag
No Tags, Be the first to tag this record!
Be the first to leave a comment!
You must be logged in first

Similar Items