Role of collapsin response mediator proteins in optic nerve injury
Collapsin response mediator proteins (CRMPs), also known as dihydropyrimidine-like proteins, contain five isoforms (CRMP1, CRMP2, CRMP3, CRMP4, CRMP5). In central nervous system, CRMPs are mainly involved in a variety of physiological processes such as neuronal differentiation and migration, synapti...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2025-01-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-1-102.pdf |
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| author | ZHU Yuchun, XI Xinyuan, YANG Zhen, FENG Dongfu |
| author_facet | ZHU Yuchun, XI Xinyuan, YANG Zhen, FENG Dongfu |
| author_sort | ZHU Yuchun, XI Xinyuan, YANG Zhen, FENG Dongfu |
| collection | DOAJ |
| description | Collapsin response mediator proteins (CRMPs), also known as dihydropyrimidine-like proteins, contain five isoforms (CRMP1, CRMP2, CRMP3, CRMP4, CRMP5). In central nervous system, CRMPs are mainly involved in a variety of physiological processes such as neuronal differentiation and migration, synaptic plasticity, neurite growth and development and guiding extension. Recent studies have found that inhibiting or reducing the phosphorylation of CRMPs can affect the survival and axonal regeneration of retinal ganglion cells (RGCs) after optic nerve injury, which may provide new ideas for the treatment of optic nerve injury in the future. |
| format | Article |
| id | doaj-art-f73ca824c7d84cf0ab1bb5aeaa6a548b |
| institution | Kabale University |
| issn | 1001-6325 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj-art-f73ca824c7d84cf0ab1bb5aeaa6a548b2025-08-20T03:44:35ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252025-01-0145110210610.16352/j.issn.1001-6325.2025.01.0102Role of collapsin response mediator proteins in optic nerve injuryZHU Yuchun, XI Xinyuan, YANG Zhen, FENG Dongfu01. Department of Neurosurgery, Shanghai Jiaotong University Affiliated Sixth People′s Hospital South Campus, Shanghai 201499; ;2. Institute of Trauma Medicine, Shanghai Jiaotong University School of Medicine, Shanghai 201999, ChinaCollapsin response mediator proteins (CRMPs), also known as dihydropyrimidine-like proteins, contain five isoforms (CRMP1, CRMP2, CRMP3, CRMP4, CRMP5). In central nervous system, CRMPs are mainly involved in a variety of physiological processes such as neuronal differentiation and migration, synaptic plasticity, neurite growth and development and guiding extension. Recent studies have found that inhibiting or reducing the phosphorylation of CRMPs can affect the survival and axonal regeneration of retinal ganglion cells (RGCs) after optic nerve injury, which may provide new ideas for the treatment of optic nerve injury in the future.https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-1-102.pdfcollapsin response mediator proteins|optic nerve injury|retinal ganglion cell|axonal regeneration |
| spellingShingle | ZHU Yuchun, XI Xinyuan, YANG Zhen, FENG Dongfu Role of collapsin response mediator proteins in optic nerve injury Jichu yixue yu linchuang collapsin response mediator proteins|optic nerve injury|retinal ganglion cell|axonal regeneration |
| title | Role of collapsin response mediator proteins in optic nerve injury |
| title_full | Role of collapsin response mediator proteins in optic nerve injury |
| title_fullStr | Role of collapsin response mediator proteins in optic nerve injury |
| title_full_unstemmed | Role of collapsin response mediator proteins in optic nerve injury |
| title_short | Role of collapsin response mediator proteins in optic nerve injury |
| title_sort | role of collapsin response mediator proteins in optic nerve injury |
| topic | collapsin response mediator proteins|optic nerve injury|retinal ganglion cell|axonal regeneration |
| url | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-1-102.pdf |
| work_keys_str_mv | AT zhuyuchunxixinyuanyangzhenfengdongfu roleofcollapsinresponsemediatorproteinsinopticnerveinjury |