Full‐active pharmaceutical ingredient nanosensitizer for augmented photoimmunotherapy by synergistic mitochondria targeting and immunogenic death inducing
Abstract The precise and effective activation of the immune response is crucial in promising therapy curing cancer. Photoimmunotherapy (PIT) is an emerging strategy for precise regulation and highly spatiotemporal selectivity. However, this approach faces a significant challenge due to the off‐targe...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | MedComm |
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| Online Access: | https://doi.org/10.1002/mco2.756 |
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| author | Xianghui Li Haoran Wang Zhiyan Li Song Liu Yuanyuan Chen Zhuren Ruan Zhijian Yao Gao Wei Cunwei Cao Wenjun Zheng Wenxian Guan |
| author_facet | Xianghui Li Haoran Wang Zhiyan Li Song Liu Yuanyuan Chen Zhuren Ruan Zhijian Yao Gao Wei Cunwei Cao Wenjun Zheng Wenxian Guan |
| author_sort | Xianghui Li |
| collection | DOAJ |
| description | Abstract The precise and effective activation of the immune response is crucial in promising therapy curing cancer. Photoimmunotherapy (PIT) is an emerging strategy for precise regulation and highly spatiotemporal selectivity. However, this approach faces a significant challenge due to the off‐target effect and the immunosuppressive microenvironment. To address this challenge, a nanoscale full‐active pharmaceutical ingredient (API) photo‐immune stimulator was developed. This formulation overcomes the limitations of PIT by strengthening the ability to penetrate tumors deeply and inducing precise and potent mitochondria‐targeted dual‐mode photodynamic therapy and photothermal therapy. Along with inhibiting overexpressed Hsp90, this nanosensitizer in turn improves the immunosuppressive microenvironment. Ultimately, this mitochondria‐targeted PIT demonstrated potent antitumor efficacy, achieving a remarkable inhibition rate of ≥95% for both established primary tumors and distant abscopal tumors. In conclusion, this novel self‐delivery full‐API nanosystem enhances the efficacy of phototherapy and reprograms the immunosuppressive microenvironment, thereby holding great promise in the development of precise and effective immunotherapy. |
| format | Article |
| id | doaj-art-f72541df1e2246e39efa0bb73873cf5a |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-f72541df1e2246e39efa0bb73873cf5a2024-11-14T16:14:36ZengWileyMedComm2688-26632024-11-01511n/an/a10.1002/mco2.756Full‐active pharmaceutical ingredient nanosensitizer for augmented photoimmunotherapy by synergistic mitochondria targeting and immunogenic death inducingXianghui Li0Haoran Wang1Zhiyan Li2Song Liu3Yuanyuan Chen4Zhuren Ruan5Zhijian Yao6Gao Wei7Cunwei Cao8Wenjun Zheng9Wenxian Guan10Department of Dermatology and VenereologyThe First Affiliated Hospital of Guangxi Medical UniversityNanning ChinaState Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent ManufactureNanjing University of Chinese MedicineNanjingChinaDepartment of Gastrointestinal SurgeryAffiliated Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjingChinaDepartment of Gastrointestinal SurgeryAffiliated Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjingChinaDepartment of Dermatology and VenereologyThe First Affiliated Hospital of Guangxi Medical UniversityNanning ChinaDepartment of Dermatology and VenereologyThe First Affiliated Hospital of Guangxi Medical UniversityNanning ChinaDepartment of Dermatology and VenereologyThe First Affiliated Hospital of Guangxi Medical UniversityNanning ChinaDepartment of Dermatology and VenereologyThe First Affiliated Hospital of Guangxi Medical UniversityNanning ChinaDepartment of Dermatology and VenereologyThe First Affiliated Hospital of Guangxi Medical UniversityNanning ChinaDepartment of Dermatology and VenereologyThe First Affiliated Hospital of Guangxi Medical UniversityNanning ChinaDepartment of Gastrointestinal SurgeryAffiliated Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjingChinaAbstract The precise and effective activation of the immune response is crucial in promising therapy curing cancer. Photoimmunotherapy (PIT) is an emerging strategy for precise regulation and highly spatiotemporal selectivity. However, this approach faces a significant challenge due to the off‐target effect and the immunosuppressive microenvironment. To address this challenge, a nanoscale full‐active pharmaceutical ingredient (API) photo‐immune stimulator was developed. This formulation overcomes the limitations of PIT by strengthening the ability to penetrate tumors deeply and inducing precise and potent mitochondria‐targeted dual‐mode photodynamic therapy and photothermal therapy. Along with inhibiting overexpressed Hsp90, this nanosensitizer in turn improves the immunosuppressive microenvironment. Ultimately, this mitochondria‐targeted PIT demonstrated potent antitumor efficacy, achieving a remarkable inhibition rate of ≥95% for both established primary tumors and distant abscopal tumors. In conclusion, this novel self‐delivery full‐API nanosystem enhances the efficacy of phototherapy and reprograms the immunosuppressive microenvironment, thereby holding great promise in the development of precise and effective immunotherapy.https://doi.org/10.1002/mco2.756full‐API nanosystemheat shock proteinimmunogenic cell deathmitochondria targetingphotoimmunotherapy |
| spellingShingle | Xianghui Li Haoran Wang Zhiyan Li Song Liu Yuanyuan Chen Zhuren Ruan Zhijian Yao Gao Wei Cunwei Cao Wenjun Zheng Wenxian Guan Full‐active pharmaceutical ingredient nanosensitizer for augmented photoimmunotherapy by synergistic mitochondria targeting and immunogenic death inducing MedComm full‐API nanosystem heat shock protein immunogenic cell death mitochondria targeting photoimmunotherapy |
| title | Full‐active pharmaceutical ingredient nanosensitizer for augmented photoimmunotherapy by synergistic mitochondria targeting and immunogenic death inducing |
| title_full | Full‐active pharmaceutical ingredient nanosensitizer for augmented photoimmunotherapy by synergistic mitochondria targeting and immunogenic death inducing |
| title_fullStr | Full‐active pharmaceutical ingredient nanosensitizer for augmented photoimmunotherapy by synergistic mitochondria targeting and immunogenic death inducing |
| title_full_unstemmed | Full‐active pharmaceutical ingredient nanosensitizer for augmented photoimmunotherapy by synergistic mitochondria targeting and immunogenic death inducing |
| title_short | Full‐active pharmaceutical ingredient nanosensitizer for augmented photoimmunotherapy by synergistic mitochondria targeting and immunogenic death inducing |
| title_sort | full active pharmaceutical ingredient nanosensitizer for augmented photoimmunotherapy by synergistic mitochondria targeting and immunogenic death inducing |
| topic | full‐API nanosystem heat shock protein immunogenic cell death mitochondria targeting photoimmunotherapy |
| url | https://doi.org/10.1002/mco2.756 |
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