The association of serum total bile acids and deep venous thrombosis
Summary Background and aim Bile acid metabolism plays a crucial role in maintaining the delicate balance between coagulation and anticoagulation processes. However, there is a paucity of research exploring the relationship between serum total bile acids (TBA) levels and the risk of deep venous throm...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12959-024-00683-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841544402592333824 |
|---|---|
| author | Bolin Li Xinxin Feng Xinping Kang Yi Zhao Miaomiao Cao Bao Xu Hui Liu Shuyi Deng Yue Wu Tao Zheng |
| author_facet | Bolin Li Xinxin Feng Xinping Kang Yi Zhao Miaomiao Cao Bao Xu Hui Liu Shuyi Deng Yue Wu Tao Zheng |
| author_sort | Bolin Li |
| collection | DOAJ |
| description | Summary Background and aim Bile acid metabolism plays a crucial role in maintaining the delicate balance between coagulation and anticoagulation processes. However, there is a paucity of research exploring the relationship between serum total bile acids (TBA) levels and the risk of deep venous thrombosis (DVT) in Chinese individuals. The primary objective of this study is to investigate the association between TBA levels and DVT occurrence in this population. Methods and results A cross-sectional study was conducted involving 4522 patients with suspected DVT, recruited from June 2018 to October 2023, at the First Affiliated Hospital of Xi’an Jiaotong University. After rigorous screening, 3165 patients were included in the final analysis. Participants were categorized into three TBA level groups: low-level (TBA < 2.3 umol/L), moderate-level (2.3 ≤ TBA < 4.3 umol/L), and high-level (TBA ≥ 4.3 umol/L). Logistic regression analysis was utilized to assess the relationship between TBA levels and DVT risk, adjusting for potential confounders. The median age of the study population was 63 years, with a median TBA level of 3.2 (1.9–5.3) umol/L. The findings revealed that, compared to the low-level TBA group, the moderate and high-level TBA groups had significantly higher odds ratios (ORs) for DVT, with ORs of 1.47 (95% CI: 1.21 to 1.78, P < 0.001) and 1.91 (95% CI: 1.58 to 2.32, P < 0.001), respectively. Interestingly, higher TBA levels were also associated with reduced odds of bleeding risk, with ORs of 0.81 (95% CI: 0.63 to 1.03, P < 0.001) and 0.64 (95% CI: 0.5 to 0.81, P < 0.001), respectively. Conclusions Our study provides evidence that serum TBA levels may serve as a risk factor for DVT in Chinese individuals, with higher levels conferring an increased risk. Additionally, unexpectedly, higher TBA levels were found to be associated with a reduced risk of bleeding complications. These findings have significant implications for understanding the complex interplay between bile acid metabolism and deep venous thrombosis, and warrant further investigation. |
| format | Article |
| id | doaj-art-f71692e9e4ac4ce495e6b8ca16641ef4 |
| institution | Kabale University |
| issn | 1477-9560 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj-art-f71692e9e4ac4ce495e6b8ca16641ef42025-01-12T12:35:56ZengBMCThrombosis Journal1477-95602025-01-012311810.1186/s12959-024-00683-8The association of serum total bile acids and deep venous thrombosisBolin Li0Xinxin Feng1Xinping Kang2Yi Zhao3Miaomiao Cao4Bao Xu5Hui Liu6Shuyi Deng7Yue Wu8Tao Zheng9Department of Cardiology, The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong UniversityDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Neurology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Radiology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Cardiology, The Third People’s Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong UniversityBiobank, The first Affiliated Hospital of Xi’an Jiaotong UniversityFifth Outpatient Department, Xijing 986 HospitalDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Cardiovascular Medicine, The First Affiliated Hospital of Xi’an Jiaotong UniversitySummary Background and aim Bile acid metabolism plays a crucial role in maintaining the delicate balance between coagulation and anticoagulation processes. However, there is a paucity of research exploring the relationship between serum total bile acids (TBA) levels and the risk of deep venous thrombosis (DVT) in Chinese individuals. The primary objective of this study is to investigate the association between TBA levels and DVT occurrence in this population. Methods and results A cross-sectional study was conducted involving 4522 patients with suspected DVT, recruited from June 2018 to October 2023, at the First Affiliated Hospital of Xi’an Jiaotong University. After rigorous screening, 3165 patients were included in the final analysis. Participants were categorized into three TBA level groups: low-level (TBA < 2.3 umol/L), moderate-level (2.3 ≤ TBA < 4.3 umol/L), and high-level (TBA ≥ 4.3 umol/L). Logistic regression analysis was utilized to assess the relationship between TBA levels and DVT risk, adjusting for potential confounders. The median age of the study population was 63 years, with a median TBA level of 3.2 (1.9–5.3) umol/L. The findings revealed that, compared to the low-level TBA group, the moderate and high-level TBA groups had significantly higher odds ratios (ORs) for DVT, with ORs of 1.47 (95% CI: 1.21 to 1.78, P < 0.001) and 1.91 (95% CI: 1.58 to 2.32, P < 0.001), respectively. Interestingly, higher TBA levels were also associated with reduced odds of bleeding risk, with ORs of 0.81 (95% CI: 0.63 to 1.03, P < 0.001) and 0.64 (95% CI: 0.5 to 0.81, P < 0.001), respectively. Conclusions Our study provides evidence that serum TBA levels may serve as a risk factor for DVT in Chinese individuals, with higher levels conferring an increased risk. Additionally, unexpectedly, higher TBA levels were found to be associated with a reduced risk of bleeding complications. These findings have significant implications for understanding the complex interplay between bile acid metabolism and deep venous thrombosis, and warrant further investigation.https://doi.org/10.1186/s12959-024-00683-8Deep venous thrombosisTotal bile acidsBleeding risk |
| spellingShingle | Bolin Li Xinxin Feng Xinping Kang Yi Zhao Miaomiao Cao Bao Xu Hui Liu Shuyi Deng Yue Wu Tao Zheng The association of serum total bile acids and deep venous thrombosis Thrombosis Journal Deep venous thrombosis Total bile acids Bleeding risk |
| title | The association of serum total bile acids and deep venous thrombosis |
| title_full | The association of serum total bile acids and deep venous thrombosis |
| title_fullStr | The association of serum total bile acids and deep venous thrombosis |
| title_full_unstemmed | The association of serum total bile acids and deep venous thrombosis |
| title_short | The association of serum total bile acids and deep venous thrombosis |
| title_sort | association of serum total bile acids and deep venous thrombosis |
| topic | Deep venous thrombosis Total bile acids Bleeding risk |
| url | https://doi.org/10.1186/s12959-024-00683-8 |
| work_keys_str_mv | AT bolinli theassociationofserumtotalbileacidsanddeepvenousthrombosis AT xinxinfeng theassociationofserumtotalbileacidsanddeepvenousthrombosis AT xinpingkang theassociationofserumtotalbileacidsanddeepvenousthrombosis AT yizhao theassociationofserumtotalbileacidsanddeepvenousthrombosis AT miaomiaocao theassociationofserumtotalbileacidsanddeepvenousthrombosis AT baoxu theassociationofserumtotalbileacidsanddeepvenousthrombosis AT huiliu theassociationofserumtotalbileacidsanddeepvenousthrombosis AT shuyideng theassociationofserumtotalbileacidsanddeepvenousthrombosis AT yuewu theassociationofserumtotalbileacidsanddeepvenousthrombosis AT taozheng theassociationofserumtotalbileacidsanddeepvenousthrombosis AT bolinli associationofserumtotalbileacidsanddeepvenousthrombosis AT xinxinfeng associationofserumtotalbileacidsanddeepvenousthrombosis AT xinpingkang associationofserumtotalbileacidsanddeepvenousthrombosis AT yizhao associationofserumtotalbileacidsanddeepvenousthrombosis AT miaomiaocao associationofserumtotalbileacidsanddeepvenousthrombosis AT baoxu associationofserumtotalbileacidsanddeepvenousthrombosis AT huiliu associationofserumtotalbileacidsanddeepvenousthrombosis AT shuyideng associationofserumtotalbileacidsanddeepvenousthrombosis AT yuewu associationofserumtotalbileacidsanddeepvenousthrombosis AT taozheng associationofserumtotalbileacidsanddeepvenousthrombosis |