Giardia duodenalis stabilizes HIF-1α and induces glycolytic alterations in intestinal epithelial cells

Giardia duodenalis stabilizes HIF-1α and induces glycolytic alterations in intestinal epithelial cells

Abstract The gastrointestinal epithelium relies on activation of the hypoxia-inducible factor (HIF) to promote cell survival and maintain bioenergetic homeostasis during hypoxia. While many pathogens can activate HIF, the effects of enteric protozoa on HIF activation in gastrointestinal epithelial c...

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Bibliographic Details
Main Authors: Emily DeMichele, Olivia Sosnowski, Darragh Flood, Cormac T. Taylor, Ian A. Lewis, Thibault Allain, Andre G. Buret
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Giardia
Giardiasis
Intestinal epithelial cells
Hypoxia
HIF-1α
Glycolysis
Online Access:https://doi.org/10.1038/s41598-025-13635-7
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