Serum vitamin D level alterations in retinal vascular occlusions
Aim: To evaluate serum vitamin D levels in sub-types of retinal vascular occlusions and compare the levels in ischemic and non-ischemic presentations. Methods: This study included 50 patients of retinal vascular occlusions comprising central retinal vein occlusion, branch retinal vein occlusion, cen...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-02-01
|
| Series: | Photodiagnosis and Photodynamic Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100023005823 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846128291277176832 |
|---|---|
| author | Rohit Bhanot Ashok Kumar Sandeep Shankar Ankita Singh Vikas Ambiya D Srujana |
| author_facet | Rohit Bhanot Ashok Kumar Sandeep Shankar Ankita Singh Vikas Ambiya D Srujana |
| author_sort | Rohit Bhanot |
| collection | DOAJ |
| description | Aim: To evaluate serum vitamin D levels in sub-types of retinal vascular occlusions and compare the levels in ischemic and non-ischemic presentations. Methods: This study included 50 patients of retinal vascular occlusions comprising central retinal vein occlusion, branch retinal vein occlusion, central retinal artery occlusion, branch retinal artery occlusion (study group) diagnosed on basis of clinical characteristics as well as investigations and an age and gender-matched healthy control group (control group). The study group was further classified into ischemic and non-ischemic subtypes and serum vitamin D levels were analysed and compared. Results: There were 50 patients of various sub-types of retinal vascular occlusions comprising 13 cases of CRVO, 30 cases of BRVO, 05 cases of CRAO, 02 cases of BRAO and 50 age and sex-matched controls. Mean BCVA and CMT in RVO patients was +1.12 log MAR, 346.72 ± 27.93 µm while in control group was +0.37 log MAR, 236.22 ± 3.71 µm which were statistically significant (p = 0.004; p = 0.002). The mean serum vitamin D value in study group was 18.39 ng/dl as compared to 32.31 ng/dl in control group which was statistically significant (p = 0.001). The difference in the baseline vitamin D value between the ischemic and non -ischemic sub groups among total vascular occlusion was found to be statistically significant (p = 0.010). However, baseline vitamin D levels difference among ischemic and non-ischemic cases in individual sub-types of vascular occlusion was statistically insignificant. Conclusion: High prevalence of low serum vitamin D levels is seen in patients of retinal vascular occlusion spectrum diseases. Moreover, ischemic types of retinal vascular occlusion have significantly lower serum vitamin D levels as compared to non – ischemic despite having fewer no of patients in arterial occlusion sub-types. Therefore, vitamin D supplements may be considered as possible future targeted therapy in optimizing the severity of disease. |
| format | Article |
| id | doaj-art-f70b695edf9f4d38a9b6f1a4d41a7990 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-f70b695edf9f4d38a9b6f1a4d41a79902024-12-11T05:55:06ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-0145103855Serum vitamin D level alterations in retinal vascular occlusionsRohit Bhanot0Ashok Kumar1Sandeep Shankar2Ankita Singh3Vikas Ambiya4D Srujana5Dept of Ophthalmology, Armed Forces Medical College, Pune, 411040, IndiaCorresponding author at: Dept of Ophthalmology, Armed Forces Medical College, Pune, 411040, India.; Dept of Ophthalmology, Armed Forces Medical College, Pune, 411040, IndiaDept of Ophthalmology, Armed Forces Medical College, Pune, 411040, IndiaDept of Ophthalmology, Armed Forces Medical College, Pune, 411040, IndiaDept of Ophthalmology, Armed Forces Medical College, Pune, 411040, IndiaDept of Ophthalmology, Armed Forces Medical College, Pune, 411040, IndiaAim: To evaluate serum vitamin D levels in sub-types of retinal vascular occlusions and compare the levels in ischemic and non-ischemic presentations. Methods: This study included 50 patients of retinal vascular occlusions comprising central retinal vein occlusion, branch retinal vein occlusion, central retinal artery occlusion, branch retinal artery occlusion (study group) diagnosed on basis of clinical characteristics as well as investigations and an age and gender-matched healthy control group (control group). The study group was further classified into ischemic and non-ischemic subtypes and serum vitamin D levels were analysed and compared. Results: There were 50 patients of various sub-types of retinal vascular occlusions comprising 13 cases of CRVO, 30 cases of BRVO, 05 cases of CRAO, 02 cases of BRAO and 50 age and sex-matched controls. Mean BCVA and CMT in RVO patients was +1.12 log MAR, 346.72 ± 27.93 µm while in control group was +0.37 log MAR, 236.22 ± 3.71 µm which were statistically significant (p = 0.004; p = 0.002). The mean serum vitamin D value in study group was 18.39 ng/dl as compared to 32.31 ng/dl in control group which was statistically significant (p = 0.001). The difference in the baseline vitamin D value between the ischemic and non -ischemic sub groups among total vascular occlusion was found to be statistically significant (p = 0.010). However, baseline vitamin D levels difference among ischemic and non-ischemic cases in individual sub-types of vascular occlusion was statistically insignificant. Conclusion: High prevalence of low serum vitamin D levels is seen in patients of retinal vascular occlusion spectrum diseases. Moreover, ischemic types of retinal vascular occlusion have significantly lower serum vitamin D levels as compared to non – ischemic despite having fewer no of patients in arterial occlusion sub-types. Therefore, vitamin D supplements may be considered as possible future targeted therapy in optimizing the severity of disease.http://www.sciencedirect.com/science/article/pii/S1572100023005823Retinal vascular occlusionsVitamin DCentral macular thickness |
| spellingShingle | Rohit Bhanot Ashok Kumar Sandeep Shankar Ankita Singh Vikas Ambiya D Srujana Serum vitamin D level alterations in retinal vascular occlusions Photodiagnosis and Photodynamic Therapy Retinal vascular occlusions Vitamin D Central macular thickness |
| title | Serum vitamin D level alterations in retinal vascular occlusions |
| title_full | Serum vitamin D level alterations in retinal vascular occlusions |
| title_fullStr | Serum vitamin D level alterations in retinal vascular occlusions |
| title_full_unstemmed | Serum vitamin D level alterations in retinal vascular occlusions |
| title_short | Serum vitamin D level alterations in retinal vascular occlusions |
| title_sort | serum vitamin d level alterations in retinal vascular occlusions |
| topic | Retinal vascular occlusions Vitamin D Central macular thickness |
| url | http://www.sciencedirect.com/science/article/pii/S1572100023005823 |
| work_keys_str_mv | AT rohitbhanot serumvitamindlevelalterationsinretinalvascularocclusions AT ashokkumar serumvitamindlevelalterationsinretinalvascularocclusions AT sandeepshankar serumvitamindlevelalterationsinretinalvascularocclusions AT ankitasingh serumvitamindlevelalterationsinretinalvascularocclusions AT vikasambiya serumvitamindlevelalterationsinretinalvascularocclusions AT dsrujana serumvitamindlevelalterationsinretinalvascularocclusions |