Studying red cell distribution width in Iraqi persons with type 2 diabetes mellitus in Najaf City: a case-control study
Background. Red cell distribution width (RDW) is a parameter measured routinely in standard blood cell counts, reflecting the variability in red cell size and volume. Numerous studies have identified a significant correlation between RDW and various health disorders, including cardiovascular disease...
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| Language: | English |
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Zaslavsky O.Yu.
2024-12-01
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| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
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| Online Access: | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1465 |
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| author | Maysam Riyadh Mohammed Hussein Alaasam Karrar Mohammed Abbas Al-buthabhak Ahmed Mech Shamim Riadh Mohammed Hussein |
| author_facet | Maysam Riyadh Mohammed Hussein Alaasam Karrar Mohammed Abbas Al-buthabhak Ahmed Mech Shamim Riadh Mohammed Hussein |
| author_sort | Maysam Riyadh Mohammed Hussein Alaasam |
| collection | DOAJ |
| description | Background. Red cell distribution width (RDW) is a parameter measured routinely in standard blood cell counts, reflecting the variability in red cell size and volume. Numerous studies have identified a significant correlation between RDW and various health disorders, including cardiovascular diseases, malignancies, obesity, and chronic kidney diseases. Purpose: to study red cell distribution width in Iraqi persons with type 2 diabetes and assess its role in providing clinical information about glycemic control. Materials and methods. This case-control study included 300 participants, 150 Iraqi persons with type 2 diabetes (77 female and 73 male) in Najaf City, and 150 healthy controls (79 female and 71 male). Age, weight, systolic blood pressure, diastolic blood pressure, complete blood count, glycated hemoglobin (HbA1c), and C-reactive protein levels were assessed. In patients with diabetes, disease duration, medications, and complications were recorded. People with a history of anemia, renal failure, heart disease, hypertension, thyroid disorder, pregnancy, and conditions leading to chronic inflammation, such as rheumatoid arthritis, diabetic neuropathy, diabetic retinopathy, and diabetic nephropathy, were excluded from the study. Results. RDW was significantly higher in people with diabetes (14.77 ± 3.56) than in healthy controls (12.19 ± 1.10), p < 0.0001. In the diabetes group, no statistically significant correlation was noted between RDW and disease duration (p = 0.143). RDW was strongly and directly associated with HbA1c and C-reactive protein levels (p < 0.0001 and р = 0.002, respectively). Conclusions. RDW was higher in people with type 2 diabetes than in healthy controls. RDW levels are affected by glycemic control because a higher HbA1c level is associated with a higher RDW. Thus, RDW can be considered a marker of glycemic control in clinical practice. |
| format | Article |
| id | doaj-art-f6fd056f198e4690b2d8c8a5459b108d |
| institution | Kabale University |
| issn | 2224-0721 2307-1427 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Mìžnarodnij Endokrinologìčnij Žurnal |
| spelling | doaj-art-f6fd056f198e4690b2d8c8a5459b108d2025-01-12T12:20:34ZengZaslavsky O.Yu.Mìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272024-12-0120858759210.22141/2224-0721.20.8.2024.14651463Studying red cell distribution width in Iraqi persons with type 2 diabetes mellitus in Najaf City: a case-control studyMaysam Riyadh Mohammed Hussein Alaasam0https://orcid.org/0000-0002-8888-8782Karrar Mohammed Abbas Al-buthabhak1https://orcid.org/0000-0001-9145-2413Ahmed Mech2https://orcid.org/0000-0003-4682-1392Shamim Riadh Mohammed Hussein3https://orcid.org/0000-0001-6478-1633Faculty of Medicine, University of Kufa, Najaf, IraqFaculty of Medicine, University of Kufa, Najaf, IraqFaculty of Medicine, University of Kufa, Najaf, IraqFaculty of Medicine, Jaber ibn Hayan Medical University, Najaf, IraqBackground. Red cell distribution width (RDW) is a parameter measured routinely in standard blood cell counts, reflecting the variability in red cell size and volume. Numerous studies have identified a significant correlation between RDW and various health disorders, including cardiovascular diseases, malignancies, obesity, and chronic kidney diseases. Purpose: to study red cell distribution width in Iraqi persons with type 2 diabetes and assess its role in providing clinical information about glycemic control. Materials and methods. This case-control study included 300 participants, 150 Iraqi persons with type 2 diabetes (77 female and 73 male) in Najaf City, and 150 healthy controls (79 female and 71 male). Age, weight, systolic blood pressure, diastolic blood pressure, complete blood count, glycated hemoglobin (HbA1c), and C-reactive protein levels were assessed. In patients with diabetes, disease duration, medications, and complications were recorded. People with a history of anemia, renal failure, heart disease, hypertension, thyroid disorder, pregnancy, and conditions leading to chronic inflammation, such as rheumatoid arthritis, diabetic neuropathy, diabetic retinopathy, and diabetic nephropathy, were excluded from the study. Results. RDW was significantly higher in people with diabetes (14.77 ± 3.56) than in healthy controls (12.19 ± 1.10), p < 0.0001. In the diabetes group, no statistically significant correlation was noted between RDW and disease duration (p = 0.143). RDW was strongly and directly associated with HbA1c and C-reactive protein levels (p < 0.0001 and р = 0.002, respectively). Conclusions. RDW was higher in people with type 2 diabetes than in healthy controls. RDW levels are affected by glycemic control because a higher HbA1c level is associated with a higher RDW. Thus, RDW can be considered a marker of glycemic control in clinical practice.https://iej.zaslavsky.com.ua/index.php/journal/article/view/1465type 2 diabetesred cell distribution widthinflammationc-reactive protein |
| spellingShingle | Maysam Riyadh Mohammed Hussein Alaasam Karrar Mohammed Abbas Al-buthabhak Ahmed Mech Shamim Riadh Mohammed Hussein Studying red cell distribution width in Iraqi persons with type 2 diabetes mellitus in Najaf City: a case-control study Mìžnarodnij Endokrinologìčnij Žurnal type 2 diabetes red cell distribution width inflammation c-reactive protein |
| title | Studying red cell distribution width in Iraqi persons with type 2 diabetes mellitus in Najaf City: a case-control study |
| title_full | Studying red cell distribution width in Iraqi persons with type 2 diabetes mellitus in Najaf City: a case-control study |
| title_fullStr | Studying red cell distribution width in Iraqi persons with type 2 diabetes mellitus in Najaf City: a case-control study |
| title_full_unstemmed | Studying red cell distribution width in Iraqi persons with type 2 diabetes mellitus in Najaf City: a case-control study |
| title_short | Studying red cell distribution width in Iraqi persons with type 2 diabetes mellitus in Najaf City: a case-control study |
| title_sort | studying red cell distribution width in iraqi persons with type 2 diabetes mellitus in najaf city a case control study |
| topic | type 2 diabetes red cell distribution width inflammation c-reactive protein |
| url | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1465 |
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