Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats

Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats

Abstract Alcohol use disorder (AUD) represents a public health crisis with few FDA-approved medications for its treatment. Growing evidence supports the key role of the bidirectional communication between the gut microbiota and the central nervous system (CNS) during the initiation and progression o...

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Bibliographic Details
Main Authors: María Elena Quintanilla, Daniela Santapau, Eugenio Diaz, Ignacio Valenzuela Martinez, Nicolas Medina, Glauben Landskron, Antonia Dominguez, Paola Morales, David Ramírez, Marcela Hermoso, Belén Olivares, Pablo Berríos-Cárcamo, Marcelo Ezquer, Mario Herrera-Marschitz, Yedy Israel, Fernando Ezquer
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Alcohol abuse
Gut microbiota-brain axis
SCFAs
Butyrate
Alcohol use disorder treatment
Online Access:https://doi.org/10.1038/s41598-024-80228-1
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