Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer
Despite regulatory approval of several immune-based treatments for cancer in the past decade, a number of barriers remain to be addressed in order to fully harness the therapeutic potential of the immune system and provide benefits for patients with cancer. As part of the Cancer Moonshot initiative,...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2020-05-01
|
| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/8/1/e000796.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846172707234775040 |
|---|---|
| author | Lawrence Fong Song Liu Eliezer Van Allen Yi Xing Ananth Annapragada Andrew Sikora Catherine Bollard Jose Conejo-Garcia Conrad Russell Cruz Shadmehr Demehri Michael Demetriou Levon Demirdjian Mary Horowitz Alan Hutson Kathryn Kadash-Edmondson Donald Kufe Steven Lipkin Claire McCarthy Martin Morgan Zachary Morris Yang Pan Marcelo Pasquini Stephen Schoenberger Eduardo Vilar Wenjuan Zha Adekunle Odunsi |
| author_facet | Lawrence Fong Song Liu Eliezer Van Allen Yi Xing Ananth Annapragada Andrew Sikora Catherine Bollard Jose Conejo-Garcia Conrad Russell Cruz Shadmehr Demehri Michael Demetriou Levon Demirdjian Mary Horowitz Alan Hutson Kathryn Kadash-Edmondson Donald Kufe Steven Lipkin Claire McCarthy Martin Morgan Zachary Morris Yang Pan Marcelo Pasquini Stephen Schoenberger Eduardo Vilar Wenjuan Zha Adekunle Odunsi |
| author_sort | Lawrence Fong |
| collection | DOAJ |
| description | Despite regulatory approval of several immune-based treatments for cancer in the past decade, a number of barriers remain to be addressed in order to fully harness the therapeutic potential of the immune system and provide benefits for patients with cancer. As part of the Cancer Moonshot initiative, the Immuno-Oncology Translational Network (IOTN) was established to accelerate the translation of basic discoveries to improve immunotherapy outcomes across the spectrum of adult cancers and to develop immune-based approaches that prevent cancers before they occur. The IOTN currently consists of 32 academic institutions in the USA. By leveraging cutting-edge preclinical research in immunotherapy and immunoprevention, open data and resource sharing, and fostering highly collaborative team science across the immuno-oncology ecosystem, the IOTN is designed to accelerate the generation of novel mechanism-driven immune-based cancer prevention and therapies, and the development of safe and effective personalized immuno-oncology approaches. |
| format | Article |
| id | doaj-art-f6e5a2f33b5f41c4abd3518e187f2e5c |
| institution | Kabale University |
| issn | 2051-1426 |
| language | English |
| publishDate | 2020-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Journal for ImmunoTherapy of Cancer |
| spelling | doaj-art-f6e5a2f33b5f41c4abd3518e187f2e5c2024-11-09T13:25:07ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262020-05-018110.1136/jitc-2020-000796Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancerLawrence Fong0Song Liu1Eliezer Van Allen2Yi Xing3Ananth Annapragada4Andrew Sikora5Catherine Bollard6Jose Conejo-Garcia7Conrad Russell Cruz8Shadmehr Demehri9Michael Demetriou10Levon Demirdjian11Mary Horowitz12Alan Hutson13Kathryn Kadash-Edmondson14Donald Kufe15Steven Lipkin16Claire McCarthy17Martin Morgan18Zachary Morris19Yang Pan20Marcelo Pasquini21Stephen Schoenberger22Eduardo Vilar23Wenjuan Zha24Adekunle Odunsi25Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA3 Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USAAff3 grid.65499.370000000121069910Dana-Farber Cancer Institute Boston MA USA7 Center for Computational and Genomic Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA1 Singleton Department of Pediatric Radiology, Texas Children’s Hospital, Houston, Texas, USA1The University of Texas MD Anderson Cancer Center, Houston, TX, USA3 Center for Cancer and Immunology Research, Children’s National Medical Center, Washington, District of Columbia, USA1H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA3 Center for Cancer and Immunology Research, Children’s National Medical Center, Washington, District of Columbia, USA5 Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts, USA6 Department of Neurology, University of California Irvine, Irvine, California, USA7 Center for Computational and Genomic Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA9 Department of Medicine, Medical College of Wisconsin and Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin, USA10 Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York, USA7 Center for Computational and Genomic Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USADepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA12 Department of Medicine, Weill Cornell Medicine, New York, New York, USA13 Division of Cancer Biology, National Cancer Institute, Rockville, Maryland, USA3 Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA1University of Wisconsin-Madison, Madison, WI, USA7 Center for Computational and Genomic Medicine, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA9 Department of Medicine, Medical College of Wisconsin and Center for International Blood and Marrow Transplant Research, Milwaukee, Wisconsin, USALaboratory of Cellular Immunology, La Jolla Institute for Immunology, La Jolla, California, USA1University of Texas MD Anderson Cancer Center, Houston, TX, USA10 Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, New York, USA17 Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USADespite regulatory approval of several immune-based treatments for cancer in the past decade, a number of barriers remain to be addressed in order to fully harness the therapeutic potential of the immune system and provide benefits for patients with cancer. As part of the Cancer Moonshot initiative, the Immuno-Oncology Translational Network (IOTN) was established to accelerate the translation of basic discoveries to improve immunotherapy outcomes across the spectrum of adult cancers and to develop immune-based approaches that prevent cancers before they occur. The IOTN currently consists of 32 academic institutions in the USA. By leveraging cutting-edge preclinical research in immunotherapy and immunoprevention, open data and resource sharing, and fostering highly collaborative team science across the immuno-oncology ecosystem, the IOTN is designed to accelerate the generation of novel mechanism-driven immune-based cancer prevention and therapies, and the development of safe and effective personalized immuno-oncology approaches.https://jitc.bmj.com/content/8/1/e000796.full |
| spellingShingle | Lawrence Fong Song Liu Eliezer Van Allen Yi Xing Ananth Annapragada Andrew Sikora Catherine Bollard Jose Conejo-Garcia Conrad Russell Cruz Shadmehr Demehri Michael Demetriou Levon Demirdjian Mary Horowitz Alan Hutson Kathryn Kadash-Edmondson Donald Kufe Steven Lipkin Claire McCarthy Martin Morgan Zachary Morris Yang Pan Marcelo Pasquini Stephen Schoenberger Eduardo Vilar Wenjuan Zha Adekunle Odunsi Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer Journal for ImmunoTherapy of Cancer |
| title | Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer |
| title_full | Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer |
| title_fullStr | Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer |
| title_full_unstemmed | Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer |
| title_short | Cancer Moonshot Immuno-Oncology Translational Network (IOTN): accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer |
| title_sort | cancer moonshot immuno oncology translational network iotn accelerating the clinical translation of basic discoveries for improving immunotherapy and immunoprevention of cancer |
| url | https://jitc.bmj.com/content/8/1/e000796.full |
| work_keys_str_mv | AT lawrencefong cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT songliu cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT eliezervanallen cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT yixing cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT ananthannapragada cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT andrewsikora cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT catherinebollard cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT joseconejogarcia cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT conradrussellcruz cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT shadmehrdemehri cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT michaeldemetriou cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT levondemirdjian cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT maryhorowitz cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT alanhutson cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT kathrynkadashedmondson cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT donaldkufe cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT stevenlipkin cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT clairemccarthy cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT martinmorgan cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT zacharymorris cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT yangpan cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT marcelopasquini cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT stephenschoenberger cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT eduardovilar cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT wenjuanzha cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer AT adekunleodunsi cancermoonshotimmunooncologytranslationalnetworkiotnacceleratingtheclinicaltranslationofbasicdiscoveriesforimprovingimmunotherapyandimmunopreventionofcancer |