CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium

CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium

IntroductionCadmium (Cd) and polystyrene microplastics (PS-MPs), two ubiquitous environmental contaminants, produce unique synergistic toxicity when co-existing. Key unanswered questions include specific effects on liver function and potential mechanisms.MethodsIn this study, C57BL/6 mice and AML12...

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Bibliographic Details
Main Authors: Zhixuan Chen, Huayi Qu, Jian Sun, Tao Wang, Yan Yuan, Jianhong Gu, Jianchun Bian, Zongping Liu, Hui Zou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Pharmacology
Subjects:
autophagy
cadmium
liver
lipid metabolism
polystyrene microplastics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1533188/full
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