Prognostic Value of a Joint K‐PD Model With Tumor Size Dynamics and CA‐125 Kinetics in Recurrent Ovarian Cancer Patients: BOLD Phase II GINECO Study

Prognostic Value of a Joint K‐PD Model With Tumor Size Dynamics and CA‐125 Kinetics in Recurrent Ovarian Cancer Patients: BOLD Phase II GINECO Study

ABSTRACT In patients with recurrent advanced ovarian cancer, there is a need for companion tests to guide the development of innovative chemotherapy‐free treatments. The modeled longitudinal CA‐125 ELIMination rate constant K KELIM‐B was a major prognostic factor for progression‐free survival (PFS)...

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Main Authors: Aurore Carrot, Pauline Corbaux, Olivier Colomban, Coriolan Lebreton, Laurence Gladieff, Olivier Tredan, Frédéric Selle, Cyril Abdeddaim, Alexandra Leary, Véronique D'Hondt, Coraline Dubot, Thibaut Reverdy, Benoit You, Gilles Freyer
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Subjects:
CA‐125 antigen
kinetics
models theoretical
ovarian neoplasms
survival
Online Access:https://doi.org/10.1002/psp4.70025
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https://doi.org/10.1002/psp4.70025

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