18F-FDG PET/CT SUVmax in pleuropulmonary solitary fibrous tumors: can it be incorporated into risk classification systems for predicting recurrence?
Abstract Background Several studies have been conducted to identify the parameters associated with the aggressive course of pleuropulmonary solitary fibrous tumors (SFT) following surgical treatment, and various classification systems have been proposed for assessing risk. Methods The surgical outco...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-07-01
|
| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-025-03709-7 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849238809492848640 |
|---|---|
| author | İlteriş Türk Mehmet Çetin Necati Solak Ali Can Kayaaslan Nesrin Gürçay Ebru Tatcı Göktürk Fındık Pınar Bıçakçıoğlu Selim Şakir Erkmen Gülhan |
| author_facet | İlteriş Türk Mehmet Çetin Necati Solak Ali Can Kayaaslan Nesrin Gürçay Ebru Tatcı Göktürk Fındık Pınar Bıçakçıoğlu Selim Şakir Erkmen Gülhan |
| author_sort | İlteriş Türk |
| collection | DOAJ |
| description | Abstract Background Several studies have been conducted to identify the parameters associated with the aggressive course of pleuropulmonary solitary fibrous tumors (SFT) following surgical treatment, and various classification systems have been proposed for assessing risk. Methods The surgical outcomes of patients with pleuropulmonary SFT who underwent surgery between 2009 and 2024 at our center were retrospectively evaluated. Parameters of patients who experienced recurrence during follow-up were analyzed, and the risk classification systems proposed by Demicco were tested on our patient cohort. The pozitron emision tomography/ computed tomography (PET/CT) standart uptake value(SUVmax), which was significantly associated with recurrence, was incorporated into the modified Demicco classification, and a new classification model was developed and compared with existing models. Results Among the 79 included patients, 21.5% had intraparenchymal tumors, which were excised along with various parenchymal resections, while pleural tumors underwent mass excision. The postoperative follow-up period was 108.16 ± 44.09 months, during which 7.6% of patients experienced recurrence. Tumor size (p = 0.023), mitotic index (p < 0.001), presence of necrosis (p = 0.007), and PET/CT SUVmax value (p = 0.005) were found to be significantly associated with recurrence. The PET/CT SUVmax value, which was not included in Demicco’s classifications, ranged from 1.12 to 7.98, with a cutoff value of 4.50. The addition of SUVmax to the modified Demicco classification categorized all patients with recurrence into the high-risk group, and the new classification model strongly differentiated recurrence (p < 0.01, 100% sensitivity, 71.43% specificity). Conclusion The incorporation of SUVmax into the modified Demicco classification system for pleuropulmonary SFT provides a more significant prediction of recurrence. |
| format | Article |
| id | doaj-art-f6a0a46d9ea34af2b4d8e7f9c6a4f2c4 |
| institution | Kabale University |
| issn | 1471-2466 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj-art-f6a0a46d9ea34af2b4d8e7f9c6a4f2c42025-08-20T04:01:24ZengBMCBMC Pulmonary Medicine1471-24662025-07-012511910.1186/s12890-025-03709-718F-FDG PET/CT SUVmax in pleuropulmonary solitary fibrous tumors: can it be incorporated into risk classification systems for predicting recurrence?İlteriş Türk0Mehmet Çetin1Necati Solak2Ali Can Kayaaslan3Nesrin Gürçay4Ebru Tatcı5Göktürk Fındık6Pınar Bıçakçıoğlu7Selim Şakir Erkmen Gülhan8Department of Thoracic Surgery, University of Health Sciences, Atatürk Sanatoryum Training and Research HospitalDepartment of Thoracic Surgery, Ankara Etlik City HospitalDepartment of Thoracic Surgery, Ankara Etlik City HospitalDepartment of Thoracic Surgery, University of Health Sciences, Atatürk Sanatoryum Training and Research HospitalDepartment of Pathology, University of Health Sciences, Atatürk Sanatoryum Training and Research HospitalDepartment of Nuclear Medicine, Ankara Etlik City HospitalDepartment of Thoracic Surgery, University of Health Sciences, Atatürk Sanatoryum Training and Research HospitalDepartment of Thoracic Surgery, University of Health Sciences, Atatürk Sanatoryum Training and Research HospitalDepartment of Thoracic Surgery, University of Health Sciences, Atatürk Sanatoryum Training and Research HospitalAbstract Background Several studies have been conducted to identify the parameters associated with the aggressive course of pleuropulmonary solitary fibrous tumors (SFT) following surgical treatment, and various classification systems have been proposed for assessing risk. Methods The surgical outcomes of patients with pleuropulmonary SFT who underwent surgery between 2009 and 2024 at our center were retrospectively evaluated. Parameters of patients who experienced recurrence during follow-up were analyzed, and the risk classification systems proposed by Demicco were tested on our patient cohort. The pozitron emision tomography/ computed tomography (PET/CT) standart uptake value(SUVmax), which was significantly associated with recurrence, was incorporated into the modified Demicco classification, and a new classification model was developed and compared with existing models. Results Among the 79 included patients, 21.5% had intraparenchymal tumors, which were excised along with various parenchymal resections, while pleural tumors underwent mass excision. The postoperative follow-up period was 108.16 ± 44.09 months, during which 7.6% of patients experienced recurrence. Tumor size (p = 0.023), mitotic index (p < 0.001), presence of necrosis (p = 0.007), and PET/CT SUVmax value (p = 0.005) were found to be significantly associated with recurrence. The PET/CT SUVmax value, which was not included in Demicco’s classifications, ranged from 1.12 to 7.98, with a cutoff value of 4.50. The addition of SUVmax to the modified Demicco classification categorized all patients with recurrence into the high-risk group, and the new classification model strongly differentiated recurrence (p < 0.01, 100% sensitivity, 71.43% specificity). Conclusion The incorporation of SUVmax into the modified Demicco classification system for pleuropulmonary SFT provides a more significant prediction of recurrence.https://doi.org/10.1186/s12890-025-03709-7RecurrenceSolitary fibrous tumorSurgerySUVmax |
| spellingShingle | İlteriş Türk Mehmet Çetin Necati Solak Ali Can Kayaaslan Nesrin Gürçay Ebru Tatcı Göktürk Fındık Pınar Bıçakçıoğlu Selim Şakir Erkmen Gülhan 18F-FDG PET/CT SUVmax in pleuropulmonary solitary fibrous tumors: can it be incorporated into risk classification systems for predicting recurrence? BMC Pulmonary Medicine Recurrence Solitary fibrous tumor Surgery SUVmax |
| title | 18F-FDG PET/CT SUVmax in pleuropulmonary solitary fibrous tumors: can it be incorporated into risk classification systems for predicting recurrence? |
| title_full | 18F-FDG PET/CT SUVmax in pleuropulmonary solitary fibrous tumors: can it be incorporated into risk classification systems for predicting recurrence? |
| title_fullStr | 18F-FDG PET/CT SUVmax in pleuropulmonary solitary fibrous tumors: can it be incorporated into risk classification systems for predicting recurrence? |
| title_full_unstemmed | 18F-FDG PET/CT SUVmax in pleuropulmonary solitary fibrous tumors: can it be incorporated into risk classification systems for predicting recurrence? |
| title_short | 18F-FDG PET/CT SUVmax in pleuropulmonary solitary fibrous tumors: can it be incorporated into risk classification systems for predicting recurrence? |
| title_sort | 18f fdg pet ct suvmax in pleuropulmonary solitary fibrous tumors can it be incorporated into risk classification systems for predicting recurrence |
| topic | Recurrence Solitary fibrous tumor Surgery SUVmax |
| url | https://doi.org/10.1186/s12890-025-03709-7 |
| work_keys_str_mv | AT ilteristurk 18ffdgpetctsuvmaxinpleuropulmonarysolitaryfibroustumorscanitbeincorporatedintoriskclassificationsystemsforpredictingrecurrence AT mehmetcetin 18ffdgpetctsuvmaxinpleuropulmonarysolitaryfibroustumorscanitbeincorporatedintoriskclassificationsystemsforpredictingrecurrence AT necatisolak 18ffdgpetctsuvmaxinpleuropulmonarysolitaryfibroustumorscanitbeincorporatedintoriskclassificationsystemsforpredictingrecurrence AT alicankayaaslan 18ffdgpetctsuvmaxinpleuropulmonarysolitaryfibroustumorscanitbeincorporatedintoriskclassificationsystemsforpredictingrecurrence AT nesringurcay 18ffdgpetctsuvmaxinpleuropulmonarysolitaryfibroustumorscanitbeincorporatedintoriskclassificationsystemsforpredictingrecurrence AT ebrutatcı 18ffdgpetctsuvmaxinpleuropulmonarysolitaryfibroustumorscanitbeincorporatedintoriskclassificationsystemsforpredictingrecurrence AT gokturkfındık 18ffdgpetctsuvmaxinpleuropulmonarysolitaryfibroustumorscanitbeincorporatedintoriskclassificationsystemsforpredictingrecurrence AT pınarbıcakcıoglu 18ffdgpetctsuvmaxinpleuropulmonarysolitaryfibroustumorscanitbeincorporatedintoriskclassificationsystemsforpredictingrecurrence AT selimsakirerkmengulhan 18ffdgpetctsuvmaxinpleuropulmonarysolitaryfibroustumorscanitbeincorporatedintoriskclassificationsystemsforpredictingrecurrence |