Injured tubule derived CCN1 exacerbates renal congestion-mediated acute kidney injury and fibrosis

Injured tubule derived CCN1 exacerbates renal congestion-mediated acute kidney injury and fibrosis

Abstract Epidemiological studies show that heart failure often leads to kidney dysfunction, known as cardio-renal syndrome (CRS). Elevated central venous pressure, rather than low cardiac output, strongly correlates with worsening renal function and is increasingly recognized as the cause of CRS. Ho...

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Main Authors: Atsushi Minamida, Tomohiro Nakata, Ryo Kurose, Shinji Sawai, Masashi Nakamura, Minato Umehara, Hiroko Yamauchi-Sawada, Yasuto Sunahara, Yayoi Matoba, Natsuko Okuno-Ozeki, Itaru Nakamura, Kunihiro Nakai, Noriyuki Yamashita, Yuhei Kirita, Keiichi Tamagaki, Satoaki Matoba, Tetsuro Kusaba
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Acute kidney injury with renal congestion
CCN1
Focal adhesion kinase
Online Access:https://doi.org/10.1038/s41598-025-05723-5
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