Enhancement of reactive oxygen species production by ultra-short electron pulses
The development of laser-driven accelerators-on-chip has provided an opportunity to miniaturize devices for electron radiotherapy delivery. Laser-driven accelerators produce highly time-compressed electron pulses, on the 100 fs to 1 ps scale. This delivers electrons at high peak power yet low averag...
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| Format: | Article |
| Language: | English |
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The Royal Society
2024-11-01
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| Series: | Royal Society Open Science |
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| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsos.240898 |
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| author | J. Tye O. Solgaard R. J. England J. V. Trapp A. Fielding C. P. Brown |
| author_facet | J. Tye O. Solgaard R. J. England J. V. Trapp A. Fielding C. P. Brown |
| author_sort | J. Tye |
| collection | DOAJ |
| description | The development of laser-driven accelerators-on-chip has provided an opportunity to miniaturize devices for electron radiotherapy delivery. Laser-driven accelerators produce highly time-compressed electron pulses, on the 100 fs to 1 ps scale. This delivers electrons at high peak power yet low average beam current compared with conventional delivery devices, which generate pulses of approximately 3 µs. The biophysical effects of this time structure, however, are unclear. Here, we use a Monte Carlo simulation approach to explore the effects of the electron beam time structure on the production of reactive oxygen species (ROS) in water. Our results show a power law increase in the generation of hydroxyl ions per deposited electron with decreasing pulse length over the pulse length range of 10 µs to 100 fs. Similar trends were observed for hydrogen peroxide, superoxide, hydroperoxyl, hydronium and solvated electrons. In practical terms, this indicates a fourfold increase in the efficiency of free radical production for sub-picosecond pulses, relative to that of conventional microsecond pulses, for the same number of deposited electrons. |
| format | Article |
| id | doaj-art-f68fe7432fcf4c0eae6d02270782c4dd |
| institution | Kabale University |
| issn | 2054-5703 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Royal Society Open Science |
| spelling | doaj-art-f68fe7432fcf4c0eae6d02270782c4dd2024-11-13T00:05:17ZengThe Royal SocietyRoyal Society Open Science2054-57032024-11-01111110.1098/rsos.240898Enhancement of reactive oxygen species production by ultra-short electron pulsesJ. Tye0O. Solgaard1R. J. England2J. V. Trapp3A. Fielding4C. P. Brown5MMPE, Faculty of Engineering, Queensland University of Technology, Brisbane, Queensland, AustraliaEdward L. Ginzton Laboratory, Department of Electrical Engineering, Stanford University, Stanford, CA, USASLAC National Accelerator Laboratory, Menlo Park, CA, USASchool of Chemistry and Physics, Faculty of Science, Queensland University of Technology, Brisbane, Queensland, AustraliaCentre for Biomedical Technology, Queensland University of Technology, Brisbane, Queensland, AustraliaMMPE, Faculty of Engineering, Queensland University of Technology, Brisbane, Queensland, AustraliaThe development of laser-driven accelerators-on-chip has provided an opportunity to miniaturize devices for electron radiotherapy delivery. Laser-driven accelerators produce highly time-compressed electron pulses, on the 100 fs to 1 ps scale. This delivers electrons at high peak power yet low average beam current compared with conventional delivery devices, which generate pulses of approximately 3 µs. The biophysical effects of this time structure, however, are unclear. Here, we use a Monte Carlo simulation approach to explore the effects of the electron beam time structure on the production of reactive oxygen species (ROS) in water. Our results show a power law increase in the generation of hydroxyl ions per deposited electron with decreasing pulse length over the pulse length range of 10 µs to 100 fs. Similar trends were observed for hydrogen peroxide, superoxide, hydroperoxyl, hydronium and solvated electrons. In practical terms, this indicates a fourfold increase in the efficiency of free radical production for sub-picosecond pulses, relative to that of conventional microsecond pulses, for the same number of deposited electrons.https://royalsocietypublishing.org/doi/10.1098/rsos.240898dielectric laser acceleratorelectron-tissue interactionelectron radiotherapyreactive oxygen speciespulse duration |
| spellingShingle | J. Tye O. Solgaard R. J. England J. V. Trapp A. Fielding C. P. Brown Enhancement of reactive oxygen species production by ultra-short electron pulses Royal Society Open Science dielectric laser accelerator electron-tissue interaction electron radiotherapy reactive oxygen species pulse duration |
| title | Enhancement of reactive oxygen species production by ultra-short electron pulses |
| title_full | Enhancement of reactive oxygen species production by ultra-short electron pulses |
| title_fullStr | Enhancement of reactive oxygen species production by ultra-short electron pulses |
| title_full_unstemmed | Enhancement of reactive oxygen species production by ultra-short electron pulses |
| title_short | Enhancement of reactive oxygen species production by ultra-short electron pulses |
| title_sort | enhancement of reactive oxygen species production by ultra short electron pulses |
| topic | dielectric laser accelerator electron-tissue interaction electron radiotherapy reactive oxygen species pulse duration |
| url | https://royalsocietypublishing.org/doi/10.1098/rsos.240898 |
| work_keys_str_mv | AT jtye enhancementofreactiveoxygenspeciesproductionbyultrashortelectronpulses AT osolgaard enhancementofreactiveoxygenspeciesproductionbyultrashortelectronpulses AT rjengland enhancementofreactiveoxygenspeciesproductionbyultrashortelectronpulses AT jvtrapp enhancementofreactiveoxygenspeciesproductionbyultrashortelectronpulses AT afielding enhancementofreactiveoxygenspeciesproductionbyultrashortelectronpulses AT cpbrown enhancementofreactiveoxygenspeciesproductionbyultrashortelectronpulses |