Impacts of highly active antiretroviral therapy (HAART) on metabolic status of patients with AIDS; what happens from the initiation of AIDS to the initiation of treatment
Long term administration of antiretroviral therapy seems to cause metabolic complications and subsequent morbidity on HIV infected patients. If alteration of metabolic parameters is associated with the severity and advancement of AIDS or the antiretroviral treatments which patients are using. In a...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1714 |
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| Summary: | Long term administration of antiretroviral therapy seems to cause metabolic complications and subsequent morbidity on HIV infected patients. If alteration of metabolic parameters is associated with the severity and advancement of AIDS or the antiretroviral treatments which patients are using.
In a case-control study on 114 HIV infected subjects and 114 matched healthy controls, we measured metabolic parameters and blood biochemistry to assess the association of HIV infection status, AIDS, and antiretroviral treatment (ART) with changes in these variables.
Mean levels of Calcium, Triglyceride, HDL-c, LDL-c, PTH, vitamin D, and platelet were significantly lower in HIV infected patients compared to HIV negative population (p< 0.01). Means levels of phosphorus and total Cholesterol (TC)/ HDL-c Ratio were significantly higher in HIV positive patients compared with the control group (p< 0.01). Considering categories of cART, only Ca and P were significantly different between these groups (p>0.05).
LDL, TC, and P are higher while HDL, PTH, 1, 25 Vit D, Ca, ALKP, and plt are lower among HIV positive patients. Among all the metabolic variables, Ca and P seemed to be associated with the type of antiretroviral regimen and were higher in NNRTI and NRTI group. |
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| ISSN: | 2035-3006 |