Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucoma
<br> Z.M. Nagornova<sup>1</sup>, A.V. Kuroyedov<sup>2,3</sup>, A.V. Seleznev<sup>1</sup><br> <sup>1</sup>Ivanovo State Medical Academy, Ivanovo, Russian Federation<br> <sup>2</sup> Central Military Clinical Hospital nam...
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| Language: | Russian |
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Prime-Media
2019-04-01
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| Series: | РМЖ "Клиническая офтальмология" |
| Online Access: | http://clinopht.com/upload/iblock/58d/58db5f00f057d008137526f57ffa857d.pdf |
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| author | Z.M. Nagornova A.V. Kuroyedov A.V. Seleznev |
| author_facet | Z.M. Nagornova A.V. Kuroyedov A.V. Seleznev |
| author_sort | Z.M. Nagornova |
| collection | DOAJ |
| description | <br>
Z.M. Nagornova<sup>1</sup>, A.V. Kuroyedov<sup>2,3</sup>, A.V. Seleznev<sup>1</sup><br>
<sup>1</sup>Ivanovo State Medical Academy, Ivanovo, Russian Federation<br>
<sup>2</sup> Central Military Clinical Hospital named after P.V. Mandryka, Moscow, Russian Federation<br>
<sup>3</sup>Pirogov Russian National Research Medical University, Moscow, Russian Federation<br>
<br>
Currently, various glaucoma medications are available at the pharmaceutical market. Among them, fixed-dose combinations are of special importance which are considered as first-line agents for some patients (i.e., with advanced glaucoma or high intraocular pressure). Fixed-dose combinations are superior to individual components through the comfortable regimen with less instillations which improves treatment compliance. Moreover, IOP-lowering effect of fixed-dose combinations is similar or even greater than that of individual components due to the lack of washout phenomenon and less toxic effect of preservatives on the ocular surface. However, there are several disadvantages of fixed-dose combinations, e.g., dosing and regimen are inflexible and cannot easily be regulated. The paper discusses the results of clinical trials which compare the efficacy and safety of the most common fixed-dose combinations and their individual components.<br>
Thus, fixed-dose combinations of prostaglandin analogues and timolol maleate demonstrate similar IOP-lowering effect as compared with individual components and less side effects.<br>
<br>
<b>Keywords</b>: primary open-angle glaucoma, fixed-dose combination, glaucoma, combined therapy, treatment efficacy.<br>
<b>For citation:</b> Nagornova Z.M., Kuroyedov A.V., Seleznev A.V. Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucoma. Russian Journal of Clinical Ophthalmology. 2019;19(1):13–19.<br> |
| format | Article |
| id | doaj-art-f6606f8077bb4d73961d5ae71a294c99 |
| institution | Kabale University |
| issn | 2311-7729 2619-1571 |
| language | Russian |
| publishDate | 2019-04-01 |
| publisher | Prime-Media |
| record_format | Article |
| series | РМЖ "Клиническая офтальмология" |
| spelling | doaj-art-f6606f8077bb4d73961d5ae71a294c992025-01-16T09:39:39ZrusPrime-MediaРМЖ "Клиническая офтальмология"2311-77292619-15712019-04-0119130580Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucomaZ.M. Nagornova0A.V. Kuroyedov1A.V. Seleznev2Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Clinical Ophthalmology, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<br> Z.M. Nagornova<sup>1</sup>, A.V. Kuroyedov<sup>2,3</sup>, A.V. Seleznev<sup>1</sup><br> <sup>1</sup>Ivanovo State Medical Academy, Ivanovo, Russian Federation<br> <sup>2</sup> Central Military Clinical Hospital named after P.V. Mandryka, Moscow, Russian Federation<br> <sup>3</sup>Pirogov Russian National Research Medical University, Moscow, Russian Federation<br> <br> Currently, various glaucoma medications are available at the pharmaceutical market. Among them, fixed-dose combinations are of special importance which are considered as first-line agents for some patients (i.e., with advanced glaucoma or high intraocular pressure). Fixed-dose combinations are superior to individual components through the comfortable regimen with less instillations which improves treatment compliance. Moreover, IOP-lowering effect of fixed-dose combinations is similar or even greater than that of individual components due to the lack of washout phenomenon and less toxic effect of preservatives on the ocular surface. However, there are several disadvantages of fixed-dose combinations, e.g., dosing and regimen are inflexible and cannot easily be regulated. The paper discusses the results of clinical trials which compare the efficacy and safety of the most common fixed-dose combinations and their individual components.<br> Thus, fixed-dose combinations of prostaglandin analogues and timolol maleate demonstrate similar IOP-lowering effect as compared with individual components and less side effects.<br> <br> <b>Keywords</b>: primary open-angle glaucoma, fixed-dose combination, glaucoma, combined therapy, treatment efficacy.<br> <b>For citation:</b> Nagornova Z.M., Kuroyedov A.V., Seleznev A.V. Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucoma. Russian Journal of Clinical Ophthalmology. 2019;19(1):13–19.<br>http://clinopht.com/upload/iblock/58d/58db5f00f057d008137526f57ffa857d.pdf |
| spellingShingle | Z.M. Nagornova A.V. Kuroyedov A.V. Seleznev Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucoma РМЖ "Клиническая офтальмология" |
| title | Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucoma |
| title_full | Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucoma |
| title_fullStr | Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucoma |
| title_full_unstemmed | Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucoma |
| title_short | Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucoma |
| title_sort | comparative analysis of the efficacy and safety of fixed dose combinations versus their individual components for open angle glaucoma |
| url | http://clinopht.com/upload/iblock/58d/58db5f00f057d008137526f57ffa857d.pdf |
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