Multi-omics approach identifies gut microbiota variations associated with depression

Abstract The gut microbiota plays a potential role in the pathophysiology of depression through the gut–brain axis. This cross-sectional study in 400 participants from the PREDIMED-Plus study investigates the interplay between gut microbiota and depression using a multi-omics approach. Depression wa...

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Main Authors: Adrián Hernández-Cacho, Jesús F. García-Gavilán, Alessandro Atzeni, Prokopis Konstanti, Clara Belzer, Jesús Vioque, Dolores Corella, Montserrat Fitó, Josep Vidal, Virginia Mela, Liming Liang, Laura Torres-Collado, Oscar Coltell, Nancy Babio, Clary Clish, Javier Hernando-Redondo, Miguel Á Martínez-González, Fenglei Wang, Isabel Moreno-Indias, Jiaqi Ni, Courtney Dennis, Miguel Ruiz-Canela, Francisco J. Tinahones, Frank B. Hu, Jordi Salas-Salvadó
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Biofilms and Microbiomes
Online Access:https://doi.org/10.1038/s41522-025-00707-9
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