Synergistic inhibition of TNBC by USP33 and TAP63 through autophagy and ferroptosis activation

Synergistic inhibition of TNBC by USP33 and TAP63 through autophagy and ferroptosis activation

Abstract Background Triple-negative breast cancer (TNBC) is an aggressive malignancy lacking effective targeted therapies. Given the growing importance of regulated cell death pathways, we investigated the role of USP33 and its interaction with the tumor suppressor TAP63 in modulating ferroptosis an...

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Bibliographic Details
Main Authors: Feilin Qu, Wei Jian, Yixiang Huang, Xiqian Zhou, Xuehui Wang, JunJie Li, Gang Wang, Mainly
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Cellular and Molecular Life Sciences
Subjects:
USP33
TAP63
Triple-Negative breast Cancer (TNBC)
Autophagy
Ferroptosis
Online Access:https://doi.org/10.1007/s00018-025-05833-3
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