miR-142-5p as a CXCR4-Targeted MicroRNA Attenuates SDF-1-Induced Chondrocyte Apoptosis and Cartilage Degradation via Inactivating MAPK Signaling Pathway

miR-142-5p as a CXCR4-Targeted MicroRNA Attenuates SDF-1-Induced Chondrocyte Apoptosis and Cartilage Degradation via Inactivating MAPK Signaling Pathway

Osteoarthritis (OA) is a chronic joint function disorder with characteristics of chondrocytes reduction and extracellular matrix (ECM) components destruction. MicroRNAs (miRNAs) and the SDF-1/CXCR4 axis are essential factors of chondrocyte apoptosis and ECM degeneration. However, very few studies ha...

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Bibliographic Details
Main Authors: Yaoyv Xiang, Yanlin Li, Lingjian Yang, Yinghong He, Di Jia, Xidan Hu
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Biochemistry Research International
Online Access:http://dx.doi.org/10.1155/2020/4508108
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