Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients
Purpose To evaluate levels of 3 tear-soluble neuropeptides in dry eye patients and to identify the correlations with clinical signs and symptoms.Methods A total of 16 dry eye patients and 12 healthy volunteers were enrolled. Dry eye disease (DED) diagnosis was based on the 2017 Report of the Tear Fi...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2451194 |
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| author | Yirou Zhang Hong Zhang Xingyu Zhu Han Ye Kan Yang Xujiao Zhou Jiaxu Hong |
| author_facet | Yirou Zhang Hong Zhang Xingyu Zhu Han Ye Kan Yang Xujiao Zhou Jiaxu Hong |
| author_sort | Yirou Zhang |
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| description | Purpose To evaluate levels of 3 tear-soluble neuropeptides in dry eye patients and to identify the correlations with clinical signs and symptoms.Methods A total of 16 dry eye patients and 12 healthy volunteers were enrolled. Dry eye disease (DED) diagnosis was based on the 2017 Report of the Tear Film & Ocular Surface Society International Dry Eye Workshop (TFOS DEWS II). First time of noninvasive breakup time (NIBUT-1st), mean time of noninvasive breakup time (NIBUT-avg), tear meniscus height (TMH), Schirmer test, corneal fluorescein staining (CFS) score and ocular surface disease index (OSDI) were recorded. Tear fluid samples were collected and enzyme-linked immunoassay (ELISA was performed to analyze levels of calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and substance P (SP), as well as the association among the 3 neuropeptides and clinical findings.Results Compared to normal controls, levels of tear CGRP (p=.003) and SP (p=.002) were significantly decreased in dry eye patients yet not NPY concentrations. Levels of tear CGRP and SP showed an inverse correlation with CFS and OSDI, which positively correlated with NIBUT-1st, NIBUT-avg and Schirmer test values. Multiple linear regression analysis showed that Schirmer test values were related to tear CGRP concentration. Subgroup analysis showed lower tear CGRP concentration in DED patients with severe symptoms (OSDI ≥ 46).Conclusions Levels of tear CGRP and SP decreased in DED patients and showed meaningful correlations with clinical symptoms and signs, implying a potential relationship between tear neuropeptides and ocular neurosensory function. |
| format | Article |
| id | doaj-art-f63409cd66b34b66bc50d6e59c6cdf2b |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-f63409cd66b34b66bc50d6e59c6cdf2b2025-01-17T17:04:59ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2451194Tear neuropeptides are associated with clinical symptoms and signs of dry eye patientsYirou Zhang0Hong Zhang1Xingyu Zhu2Han Ye3Kan Yang4Xujiao Zhou5Jiaxu Hong6Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, The First People’s Hospital of Lanzhou City, Lanzhou, Gansu, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, ChinaPurpose To evaluate levels of 3 tear-soluble neuropeptides in dry eye patients and to identify the correlations with clinical signs and symptoms.Methods A total of 16 dry eye patients and 12 healthy volunteers were enrolled. Dry eye disease (DED) diagnosis was based on the 2017 Report of the Tear Film & Ocular Surface Society International Dry Eye Workshop (TFOS DEWS II). First time of noninvasive breakup time (NIBUT-1st), mean time of noninvasive breakup time (NIBUT-avg), tear meniscus height (TMH), Schirmer test, corneal fluorescein staining (CFS) score and ocular surface disease index (OSDI) were recorded. Tear fluid samples were collected and enzyme-linked immunoassay (ELISA was performed to analyze levels of calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY) and substance P (SP), as well as the association among the 3 neuropeptides and clinical findings.Results Compared to normal controls, levels of tear CGRP (p=.003) and SP (p=.002) were significantly decreased in dry eye patients yet not NPY concentrations. Levels of tear CGRP and SP showed an inverse correlation with CFS and OSDI, which positively correlated with NIBUT-1st, NIBUT-avg and Schirmer test values. Multiple linear regression analysis showed that Schirmer test values were related to tear CGRP concentration. Subgroup analysis showed lower tear CGRP concentration in DED patients with severe symptoms (OSDI ≥ 46).Conclusions Levels of tear CGRP and SP decreased in DED patients and showed meaningful correlations with clinical symptoms and signs, implying a potential relationship between tear neuropeptides and ocular neurosensory function.https://www.tandfonline.com/doi/10.1080/07853890.2025.2451194Dry eyeneuropeptidessubstance pcalcitonin gene-related peptideneuropeptide Y |
| spellingShingle | Yirou Zhang Hong Zhang Xingyu Zhu Han Ye Kan Yang Xujiao Zhou Jiaxu Hong Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients Annals of Medicine Dry eye neuropeptides substance p calcitonin gene-related peptide neuropeptide Y |
| title | Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients |
| title_full | Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients |
| title_fullStr | Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients |
| title_full_unstemmed | Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients |
| title_short | Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients |
| title_sort | tear neuropeptides are associated with clinical symptoms and signs of dry eye patients |
| topic | Dry eye neuropeptides substance p calcitonin gene-related peptide neuropeptide Y |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2451194 |
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