Does the use of platelet-rich fibrin enhance the rate of orthodontic tooth movement? A systematic review and meta-analysis
Introduction: This review synthesizes the available evidence pertinent to the effect of platelet-rich fibrin on the rate of orthodontic tooth movement during comprehensive orthodontic treatment. Method: This review followed the Preferred Reporting Items for Systematic Review and Meta-Analysis guidel...
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Elsevier
2024-03-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426824000289 |
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| author | Jitendra Sharan Indumathi Shivakumar Arunachalam Shivakumar Vineet Kumar Kamal Prabhat Kumar Chaudhari Srikrishna Challasany Anand Marya |
| author_facet | Jitendra Sharan Indumathi Shivakumar Arunachalam Shivakumar Vineet Kumar Kamal Prabhat Kumar Chaudhari Srikrishna Challasany Anand Marya |
| author_sort | Jitendra Sharan |
| collection | DOAJ |
| description | Introduction: This review synthesizes the available evidence pertinent to the effect of platelet-rich fibrin on the rate of orthodontic tooth movement during comprehensive orthodontic treatment. Method: This review followed the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. Nine electronic databases were searched until January 2024 without restrictions, followed by a hand search of the reference lists. Controlled randomized split-mouth human studies assessing the effect of platelet-rich fibrin on the rate of orthodontic tooth movement were included. All relevant data from the included studies were extracted and pooled for qualitative and quantitative analysis. Risk-of-Bias was assessed using the Cochrane Risk of Bias tool. The certainty of the evidence was graded using the Grading of Recommendations, Assessment, Development, and Evaluation tool. Results: From 515 studies, eleven randomized clinical trials were included for qualitative analysis and nine for quantitative analysis. The certainty of the evidence for these studies was low to moderate. The overall risk of bias for most studies was of some concern. The pooled estimate of the data from ten studies has a mean revealed difference of 1.31 (0.13–2.48) at a 95 % confidence interval with significant heterogeneity. Conclusions: This systematic review suggest that platelet-rich fibrin enhances the orthodontic tooth movement rate, but the evidence quality was moderate. Further, based on the currently available evidence, the effectiveness of platelet-rich fibrin on the acceleration of orthodontic tooth movement could not be fully established. Trial registration: PROSPERO: (CRD42021261836). |
| format | Article |
| id | doaj-art-f5fc6eb57b9f404ba04b54c1ef6a3b5d |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-f5fc6eb57b9f404ba04b54c1ef6a3b5d2024-11-23T06:30:41ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682024-03-01142192200Does the use of platelet-rich fibrin enhance the rate of orthodontic tooth movement? A systematic review and meta-analysisJitendra Sharan0Indumathi Shivakumar1Arunachalam Shivakumar2Vineet Kumar Kamal3Prabhat Kumar Chaudhari4Srikrishna Challasany5Anand Marya6Unit of Orthodontics and Dentofacial Orthopedics, Department of Dentistry, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India; Corresponding author. Unit of Orthodontics and Dentofacial Orthopedics, Department of Dentistry, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.Department of Prosthodontics, Faculty of Dentistry, SEGi University, Selangor, MalaysiaDivision of Children & Community Oral Health, School of Dentistry, International Medical University, Kuala Lumpur, MalaysiaDivision of Epidemiology and Biostatistics, Indian Council of Medical Research-National Institute of Epidemiology, Chennai, IndiaDepartment of Orthodontics and Dentofacial Orthopedics, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, IndiaVisakhapatnam, Andhra Pradesh, IndiaDepartment of Orthodontics and Dentofacial Orthopedics, Faculty of Dentistry, University of Puthisastra, Phnom Penh, CambodiaIntroduction: This review synthesizes the available evidence pertinent to the effect of platelet-rich fibrin on the rate of orthodontic tooth movement during comprehensive orthodontic treatment. Method: This review followed the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. Nine electronic databases were searched until January 2024 without restrictions, followed by a hand search of the reference lists. Controlled randomized split-mouth human studies assessing the effect of platelet-rich fibrin on the rate of orthodontic tooth movement were included. All relevant data from the included studies were extracted and pooled for qualitative and quantitative analysis. Risk-of-Bias was assessed using the Cochrane Risk of Bias tool. The certainty of the evidence was graded using the Grading of Recommendations, Assessment, Development, and Evaluation tool. Results: From 515 studies, eleven randomized clinical trials were included for qualitative analysis and nine for quantitative analysis. The certainty of the evidence for these studies was low to moderate. The overall risk of bias for most studies was of some concern. The pooled estimate of the data from ten studies has a mean revealed difference of 1.31 (0.13–2.48) at a 95 % confidence interval with significant heterogeneity. Conclusions: This systematic review suggest that platelet-rich fibrin enhances the orthodontic tooth movement rate, but the evidence quality was moderate. Further, based on the currently available evidence, the effectiveness of platelet-rich fibrin on the acceleration of orthodontic tooth movement could not be fully established. Trial registration: PROSPERO: (CRD42021261836).http://www.sciencedirect.com/science/article/pii/S2212426824000289AccelerationOrthodontic tooth movementOrthodonticsPlatelet-rich fibrinHuman trialsSystematic review |
| spellingShingle | Jitendra Sharan Indumathi Shivakumar Arunachalam Shivakumar Vineet Kumar Kamal Prabhat Kumar Chaudhari Srikrishna Challasany Anand Marya Does the use of platelet-rich fibrin enhance the rate of orthodontic tooth movement? A systematic review and meta-analysis Journal of Oral Biology and Craniofacial Research Acceleration Orthodontic tooth movement Orthodontics Platelet-rich fibrin Human trials Systematic review |
| title | Does the use of platelet-rich fibrin enhance the rate of orthodontic tooth movement? A systematic review and meta-analysis |
| title_full | Does the use of platelet-rich fibrin enhance the rate of orthodontic tooth movement? A systematic review and meta-analysis |
| title_fullStr | Does the use of platelet-rich fibrin enhance the rate of orthodontic tooth movement? A systematic review and meta-analysis |
| title_full_unstemmed | Does the use of platelet-rich fibrin enhance the rate of orthodontic tooth movement? A systematic review and meta-analysis |
| title_short | Does the use of platelet-rich fibrin enhance the rate of orthodontic tooth movement? A systematic review and meta-analysis |
| title_sort | does the use of platelet rich fibrin enhance the rate of orthodontic tooth movement a systematic review and meta analysis |
| topic | Acceleration Orthodontic tooth movement Orthodontics Platelet-rich fibrin Human trials Systematic review |
| url | http://www.sciencedirect.com/science/article/pii/S2212426824000289 |
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