Late onset cerebellar ataxia syndrome after non-paraneoplastic Lambert-Eaton myasthenic syndrome: a case study
Abstract This is an unusual case of voltage gated calcium channel (VGCC) antibodies leading to two distinct and chronologically separated neurologic syndromes without the presence of an underlying neoplasm. Lambert Eaton Myasthenic Syndrome (LEMS) presented five years prior to cerebellar ataxia. Bot...
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BMC
2025-01-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-024-03983-8 |
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| author | David P. Randall Matthew C. Randall |
| author_facet | David P. Randall Matthew C. Randall |
| author_sort | David P. Randall |
| collection | DOAJ |
| description | Abstract This is an unusual case of voltage gated calcium channel (VGCC) antibodies leading to two distinct and chronologically separated neurologic syndromes without the presence of an underlying neoplasm. Lambert Eaton Myasthenic Syndrome (LEMS) presented five years prior to cerebellar ataxia. Both LEMS and cerebellar ataxia were responsive to treatment, but not the same therapy. He was diagnosed with LEMS through history, exam, electromyography/nerve conduction studies (EMG/NCS) with repetitive nerve stimulation (RNS) and antibody testing. He was treated with 3,4 diaminopyridine (3,4 DAP) with an excellent response. Five years later, he developed acute ataxia. The patient required months of intensive and continued immunomodulating therapy. |
| format | Article |
| id | doaj-art-f5f8a376c43b437bb9d8ac404c696921 |
| institution | Kabale University |
| issn | 1471-2377 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj-art-f5f8a376c43b437bb9d8ac404c6969212025-01-05T12:34:06ZengBMCBMC Neurology1471-23772025-01-012511310.1186/s12883-024-03983-8Late onset cerebellar ataxia syndrome after non-paraneoplastic Lambert-Eaton myasthenic syndrome: a case studyDavid P. Randall0Matthew C. Randall1Neuromuscular Neurology, Advocate HealthNeuromuscular Neurology, Advocate HealthAbstract This is an unusual case of voltage gated calcium channel (VGCC) antibodies leading to two distinct and chronologically separated neurologic syndromes without the presence of an underlying neoplasm. Lambert Eaton Myasthenic Syndrome (LEMS) presented five years prior to cerebellar ataxia. Both LEMS and cerebellar ataxia were responsive to treatment, but not the same therapy. He was diagnosed with LEMS through history, exam, electromyography/nerve conduction studies (EMG/NCS) with repetitive nerve stimulation (RNS) and antibody testing. He was treated with 3,4 diaminopyridine (3,4 DAP) with an excellent response. Five years later, he developed acute ataxia. The patient required months of intensive and continued immunomodulating therapy.https://doi.org/10.1186/s12883-024-03983-8Lambert-Eaton myasthenic syndromeCerebellar ataxiaVoltage-gated calcium channel antibodiesParaneoplastic cerebellar syndrome |
| spellingShingle | David P. Randall Matthew C. Randall Late onset cerebellar ataxia syndrome after non-paraneoplastic Lambert-Eaton myasthenic syndrome: a case study BMC Neurology Lambert-Eaton myasthenic syndrome Cerebellar ataxia Voltage-gated calcium channel antibodies Paraneoplastic cerebellar syndrome |
| title | Late onset cerebellar ataxia syndrome after non-paraneoplastic Lambert-Eaton myasthenic syndrome: a case study |
| title_full | Late onset cerebellar ataxia syndrome after non-paraneoplastic Lambert-Eaton myasthenic syndrome: a case study |
| title_fullStr | Late onset cerebellar ataxia syndrome after non-paraneoplastic Lambert-Eaton myasthenic syndrome: a case study |
| title_full_unstemmed | Late onset cerebellar ataxia syndrome after non-paraneoplastic Lambert-Eaton myasthenic syndrome: a case study |
| title_short | Late onset cerebellar ataxia syndrome after non-paraneoplastic Lambert-Eaton myasthenic syndrome: a case study |
| title_sort | late onset cerebellar ataxia syndrome after non paraneoplastic lambert eaton myasthenic syndrome a case study |
| topic | Lambert-Eaton myasthenic syndrome Cerebellar ataxia Voltage-gated calcium channel antibodies Paraneoplastic cerebellar syndrome |
| url | https://doi.org/10.1186/s12883-024-03983-8 |
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