Case report of non-gene editing CD7 CAR T cell therapy in CD7+ Sézary syndrome: preclinical validation and first-in-human use

IntroductionSézary syndrome (SS) is a leukemic form of cutaneous T cell lymphoma (CTCL), distinguished from mycosis fungoides by the presence of cancerous lymphocytes in the blood and often bears very poor prognoses. SS treatment is palliative, and thus novel therapies are needed. The CD7 surface an...

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Main Authors:	Haichan Xu, Lihua Sun, Zehua Wu, Vincent M. DeStefano, Masayuki Wada, Jennifer E. Chow, Hui Yi, Guoling Wang, Jing Dai, Wei Zheng, Ting Wang, Wenli Zhang, Chengxing Song, Jing Luo, Yu Ma, Benjamin Waner, Mengjie Dong, Haibo Chen, Baozhen Qin, Hongyu Zhang, Jamie Hsing-Ming Chang, Yupo Ma, Jia Feng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Immunology
Subjects:	Sézary syndrome T cell malignancy CAR T cells CD7 CAR immunotherapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604490/full
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Case report of non-gene editing CD7 CAR T cell therapy in CD7+ Sézary syndrome: preclinical validation and first-in-human use

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