TRANSFUSION PRACTICE, POST-TRANSFUSION COMPLICATIONS AND RISK FACTORS IN SICKLE CELL DISEASE IN SENEGAL, WEST AFRICA.
Context and Objectives: Blood transfusions (BT) remain a mainstay of therapy for patients with sickle cell disease (SCD), but pose significant clinical challenges. We aim to assess infectious markers, red cell alloimmunization and iron overload secondary to BT in SCD patients. Materials and Metho...
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PAGEPress Publications
2022-01-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://mjhid.org/index.php/mjhid/article/view/4743 |
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| author | Moussa Seck Alioune Badara Senghor Mossane Loum Sokhna Aissatou Touré Blaise Félix Faye Alioune Badara Diallo Mohamed Keita Elimane Seydi Bousso Sérigne Mourtalla Guèye Macoura Gadji Abibatou Sall Awa Oumar Touré Saliou Diop |
| author_facet | Moussa Seck Alioune Badara Senghor Mossane Loum Sokhna Aissatou Touré Blaise Félix Faye Alioune Badara Diallo Mohamed Keita Elimane Seydi Bousso Sérigne Mourtalla Guèye Macoura Gadji Abibatou Sall Awa Oumar Touré Saliou Diop |
| author_sort | Moussa Seck |
| collection | DOAJ |
| description | Context and Objectives: Blood transfusions (BT) remain a mainstay of therapy for patients with sickle cell disease (SCD), but pose significant clinical challenges. We aim to assess infectious markers, red cell alloimmunization and iron overload secondary to BT in SCD patients.
Materials and Methods: This is a case-control study included 253 SCD (153 SCD-transfused and 100 SCD non-transfused). We evaluated the transfusion practice (modalities, indications), post-transfusion complications (infections, alloimmunization, iron overload) and risk factors of these complications (socio-demographic, clinical, biological).
Results: Median age was 28.5 years (5 - 59). Sex ratio was 0.86. Homozygous SCD was more common (95.3%). Simple BT was performed in 92.8% and transfusion exchange in 18.9%. Transfusion indications were dominated by acute anemia (57.06%) and vaso-occlusive crisis (VOCs) (14%). Red blood cell concentrates (RBC) were administered to 93.46%. Median number of RBC received per patient was 10 (2 - 48). The prevalence of VHC in SCD-transfused was 1.33% and 2% for VHB. Anti-HIV antibodies were not found. Red cell alloimmunization frequency was 16%. The most common alloantibodies were anti-rhesus (34.19%) and anti-Kell (23.67%). Iron overload was detected in 7.84%. The number of RBC transfused was the only risk factor for alloimmunization (p = 0.03) and iron overload (p = 0.023). BT frequency was not related to infectious transmission.
Conclusion: Despite advances in blood safety, BT therapy is still a risk for SCD polytransfused patients. Although infectious transmission has rare, the risk of alloimmunization and iron overload is high in these patients. |
| format | Article |
| id | doaj-art-f5d6eea7e7a04b7db3c368887a85e759 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-f5d6eea7e7a04b7db3c368887a85e7592025-01-02T10:23:05ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062022-01-0114110.4084/MJHID.2022.004TRANSFUSION PRACTICE, POST-TRANSFUSION COMPLICATIONS AND RISK FACTORS IN SICKLE CELL DISEASE IN SENEGAL, WEST AFRICA.Moussa Seck0Alioune Badara Senghor1Mossane Loum2Sokhna Aissatou Touré3Blaise Félix Faye4Alioune Badara Diallo5Mohamed Keita6Elimane Seydi Bousso7Sérigne Mourtalla Guèye8Macoura Gadji9Abibatou Sall10Awa Oumar Touré11Saliou Diop12Moussa Seck Hematology Service, Cheikh Anta Diop University, Dakar, BP 5005, SenegalNational Blood Transfusion Center, Dakar, SenegalClinical Hematology Department, CNTS, Dakar, SenegalClinical Hematology Department, CNTS, Dakar, SenegalHematology department, Cheikh Anta Diop UniversityClinical Hematology Department, CNTS, Dakar, SenegalClinical Hematology Department, CNTS, Dakar, SenegalClinical Hematology Department, CNTS, Dakar, SenegalClinical Hematology Department, CNTS, Dakar, SenegalHematology department, Cheikh Anta Diop UniversityHematology department, Cheikh Anta Diop UniversityHematology department, Cheikh Anta Diop UniversityHematology department, Cheikh Anta Diop UniversityContext and Objectives: Blood transfusions (BT) remain a mainstay of therapy for patients with sickle cell disease (SCD), but pose significant clinical challenges. We aim to assess infectious markers, red cell alloimmunization and iron overload secondary to BT in SCD patients. Materials and Methods: This is a case-control study included 253 SCD (153 SCD-transfused and 100 SCD non-transfused). We evaluated the transfusion practice (modalities, indications), post-transfusion complications (infections, alloimmunization, iron overload) and risk factors of these complications (socio-demographic, clinical, biological). Results: Median age was 28.5 years (5 - 59). Sex ratio was 0.86. Homozygous SCD was more common (95.3%). Simple BT was performed in 92.8% and transfusion exchange in 18.9%. Transfusion indications were dominated by acute anemia (57.06%) and vaso-occlusive crisis (VOCs) (14%). Red blood cell concentrates (RBC) were administered to 93.46%. Median number of RBC received per patient was 10 (2 - 48). The prevalence of VHC in SCD-transfused was 1.33% and 2% for VHB. Anti-HIV antibodies were not found. Red cell alloimmunization frequency was 16%. The most common alloantibodies were anti-rhesus (34.19%) and anti-Kell (23.67%). Iron overload was detected in 7.84%. The number of RBC transfused was the only risk factor for alloimmunization (p = 0.03) and iron overload (p = 0.023). BT frequency was not related to infectious transmission. Conclusion: Despite advances in blood safety, BT therapy is still a risk for SCD polytransfused patients. Although infectious transmission has rare, the risk of alloimmunization and iron overload is high in these patients.https://mjhid.org/index.php/mjhid/article/view/4743Blood transfusionSickle cell diseaseInfectiousAlloimmunizationIron overload |
| spellingShingle | Moussa Seck Alioune Badara Senghor Mossane Loum Sokhna Aissatou Touré Blaise Félix Faye Alioune Badara Diallo Mohamed Keita Elimane Seydi Bousso Sérigne Mourtalla Guèye Macoura Gadji Abibatou Sall Awa Oumar Touré Saliou Diop TRANSFUSION PRACTICE, POST-TRANSFUSION COMPLICATIONS AND RISK FACTORS IN SICKLE CELL DISEASE IN SENEGAL, WEST AFRICA. Mediterranean Journal of Hematology and Infectious Diseases Blood transfusion Sickle cell disease Infectious Alloimmunization Iron overload |
| title | TRANSFUSION PRACTICE, POST-TRANSFUSION COMPLICATIONS AND RISK FACTORS IN SICKLE CELL DISEASE IN SENEGAL, WEST AFRICA. |
| title_full | TRANSFUSION PRACTICE, POST-TRANSFUSION COMPLICATIONS AND RISK FACTORS IN SICKLE CELL DISEASE IN SENEGAL, WEST AFRICA. |
| title_fullStr | TRANSFUSION PRACTICE, POST-TRANSFUSION COMPLICATIONS AND RISK FACTORS IN SICKLE CELL DISEASE IN SENEGAL, WEST AFRICA. |
| title_full_unstemmed | TRANSFUSION PRACTICE, POST-TRANSFUSION COMPLICATIONS AND RISK FACTORS IN SICKLE CELL DISEASE IN SENEGAL, WEST AFRICA. |
| title_short | TRANSFUSION PRACTICE, POST-TRANSFUSION COMPLICATIONS AND RISK FACTORS IN SICKLE CELL DISEASE IN SENEGAL, WEST AFRICA. |
| title_sort | transfusion practice post transfusion complications and risk factors in sickle cell disease in senegal west africa |
| topic | Blood transfusion Sickle cell disease Infectious Alloimmunization Iron overload |
| url | https://mjhid.org/index.php/mjhid/article/view/4743 |
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