Gambir Catechins (Uncaria gambir Roxb) Prevent Oxidative Stress in Wistar Male Rats Fed a High-Fat Diet
Objective: This study aimed to examine how gambir catechins (Uncaria gambir Roxb) affect serum malondialdehyde (MDA) levels and catalase activity in Wistar white male rats fed a high-fat diet. Methods: This is a true experimental study with a post-test-only control group design. The experiment used...
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| Format: | Article |
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Universitas Andalas
2021-12-01
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| Series: | Majalah Kedokteran Andalas |
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| Online Access: | https://jurnalmka.fk.unand.ac.id/index.php/art/article/view/860 |
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| author | Mellina Rahmi Rauza Sukma Rita Husna Yetti |
| author_facet | Mellina Rahmi Rauza Sukma Rita Husna Yetti |
| author_sort | Mellina Rahmi |
| collection | DOAJ |
| description | Objective: This study aimed to examine how gambir catechins (Uncaria gambir Roxb) affect serum malondialdehyde (MDA) levels and catalase activity in Wistar white male rats fed a high-fat diet. Methods: This is a true experimental study with a post-test-only control group design. The experiment used 30 rats divided into five groups: a negative control group, a positive control group induced by a high-fat diet, and three treatment groups caused by a high-fat diet and given gambir catechins at doses of 10 mg/kg BW/day, 20 mg/kg BW/day, and 40 mg/kg BW/day for 14 days. The TBARs method measures MDA levels, while the colorimetry method measures catalase activity. One-way ANOVA and Post Hoc Tukey HSD are used to analyze the data. Results: The gambir catechin reduced serum MDA and increased catalase activity in male Wistar strain white rats fed a considerably high-fat diet (p<0.05). Conclusion: In mice fed a high-fat diet, catechin gambir was capable of dealing with oxidative damage. |
| format | Article |
| id | doaj-art-f5cf3afa129e4fe0a87ecab8e9c976f6 |
| institution | Kabale University |
| issn | 0126-2092 2442-5230 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Universitas Andalas |
| record_format | Article |
| series | Majalah Kedokteran Andalas |
| spelling | doaj-art-f5cf3afa129e4fe0a87ecab8e9c976f62024-11-12T01:59:32ZengUniversitas AndalasMajalah Kedokteran Andalas0126-20922442-52302021-12-0144743644110.25077/mka.v44.i7.p436-441.2021489Gambir Catechins (Uncaria gambir Roxb) Prevent Oxidative Stress in Wistar Male Rats Fed a High-Fat DietMellina Rahmi0Rauza Sukma Rita1Husna Yetti2Master Program in Biomedical Science, Faculty of Medicine, Universitas Andalas, Padang, IndonesiaDepartment of Biochemistry, Faculty of Medicine, Universitas Andalas, Padang, IndonesiaDepartment of Public Health and Community Medicine, Faculty of Medicine, Universitas Andalas, Padang, IndonesiaObjective: This study aimed to examine how gambir catechins (Uncaria gambir Roxb) affect serum malondialdehyde (MDA) levels and catalase activity in Wistar white male rats fed a high-fat diet. Methods: This is a true experimental study with a post-test-only control group design. The experiment used 30 rats divided into five groups: a negative control group, a positive control group induced by a high-fat diet, and three treatment groups caused by a high-fat diet and given gambir catechins at doses of 10 mg/kg BW/day, 20 mg/kg BW/day, and 40 mg/kg BW/day for 14 days. The TBARs method measures MDA levels, while the colorimetry method measures catalase activity. One-way ANOVA and Post Hoc Tukey HSD are used to analyze the data. Results: The gambir catechin reduced serum MDA and increased catalase activity in male Wistar strain white rats fed a considerably high-fat diet (p<0.05). Conclusion: In mice fed a high-fat diet, catechin gambir was capable of dealing with oxidative damage.https://jurnalmka.fk.unand.ac.id/index.php/art/article/view/860gambir catechinmalondialdehydecatalase activityhigh-fat diet |
| spellingShingle | Mellina Rahmi Rauza Sukma Rita Husna Yetti Gambir Catechins (Uncaria gambir Roxb) Prevent Oxidative Stress in Wistar Male Rats Fed a High-Fat Diet Majalah Kedokteran Andalas gambir catechin malondialdehyde catalase activity high-fat diet |
| title | Gambir Catechins (Uncaria gambir Roxb) Prevent Oxidative Stress in Wistar Male Rats Fed a High-Fat Diet |
| title_full | Gambir Catechins (Uncaria gambir Roxb) Prevent Oxidative Stress in Wistar Male Rats Fed a High-Fat Diet |
| title_fullStr | Gambir Catechins (Uncaria gambir Roxb) Prevent Oxidative Stress in Wistar Male Rats Fed a High-Fat Diet |
| title_full_unstemmed | Gambir Catechins (Uncaria gambir Roxb) Prevent Oxidative Stress in Wistar Male Rats Fed a High-Fat Diet |
| title_short | Gambir Catechins (Uncaria gambir Roxb) Prevent Oxidative Stress in Wistar Male Rats Fed a High-Fat Diet |
| title_sort | gambir catechins uncaria gambir roxb prevent oxidative stress in wistar male rats fed a high fat diet |
| topic | gambir catechin malondialdehyde catalase activity high-fat diet |
| url | https://jurnalmka.fk.unand.ac.id/index.php/art/article/view/860 |
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