Toxoplasmosis in a case with multiple serous effusions and severe aplastic anemia
Abstract Toxoplasmosis, a parasitic disease, can cause fatal multi-organ failure in immunocompromised patients. The lack of specificity in the symptoms and the need to confirm a diagnosis of tachyzoites in fluids or tissues through microscopic examination leads to a delay in reaching a diagnosis. A...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-11-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-024-10249-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846148075376082944 |
|---|---|
| author | Xiaoning Wang Hao Li Le Ma Juan Ren Fatahichegeni Mahsa Ansarian Mohammad Amin Jing Zhao Mei Zhang Pengcheng He |
| author_facet | Xiaoning Wang Hao Li Le Ma Juan Ren Fatahichegeni Mahsa Ansarian Mohammad Amin Jing Zhao Mei Zhang Pengcheng He |
| author_sort | Xiaoning Wang |
| collection | DOAJ |
| description | Abstract Toxoplasmosis, a parasitic disease, can cause fatal multi-organ failure in immunocompromised patients. The lack of specificity in the symptoms and the need to confirm a diagnosis of tachyzoites in fluids or tissues through microscopic examination leads to a delay in reaching a diagnosis. A 28-year-old woman with severe aplastic anemia received stem cell transplantation seven months ago, presented with fever. Computed Tomography scan and ultrasonography showed moderate pleural, pericardial, peritoneal, and pelvic effusions. Metagenomic next-generation sequencing of blood and alveolar lavage fluid was done, 11,082 and 17,154 sequence readings of Toxoplasma gondii were detected, accounting for 1.34% and 17.09% of genome coverage, respectively. Then, marrow aspirate smears showed Toxoplasma gondii tachyzoites and pseudocyst. This case report alerts clinicians about Toxoplasma gondii infection in stem cell transplantation patients with multiple serous effusions and fever. Clinical trial: Not applicable. |
| format | Article |
| id | doaj-art-f5ca8eb4b5144da1aa1369a819a2419f |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-f5ca8eb4b5144da1aa1369a819a2419f2024-12-01T12:11:52ZengBMCBMC Infectious Diseases1471-23342024-11-012411410.1186/s12879-024-10249-8Toxoplasmosis in a case with multiple serous effusions and severe aplastic anemiaXiaoning Wang0Hao Li1Le Ma2Juan Ren3Fatahichegeni Mahsa4Ansarian Mohammad Amin5Jing Zhao6Mei Zhang7Pengcheng He8Department of Hematology, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Critical Care Medicine, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Hematology, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Hematology, the First Affiliated Hospital of Xi’an Jiaotong UniversityMedical College of Xi’an Jiaotong UniversityMedical College of Xi’an Jiaotong UniversityDepartment of Hematology, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Hematology, the First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Hematology, the First Affiliated Hospital of Xi’an Jiaotong UniversityAbstract Toxoplasmosis, a parasitic disease, can cause fatal multi-organ failure in immunocompromised patients. The lack of specificity in the symptoms and the need to confirm a diagnosis of tachyzoites in fluids or tissues through microscopic examination leads to a delay in reaching a diagnosis. A 28-year-old woman with severe aplastic anemia received stem cell transplantation seven months ago, presented with fever. Computed Tomography scan and ultrasonography showed moderate pleural, pericardial, peritoneal, and pelvic effusions. Metagenomic next-generation sequencing of blood and alveolar lavage fluid was done, 11,082 and 17,154 sequence readings of Toxoplasma gondii were detected, accounting for 1.34% and 17.09% of genome coverage, respectively. Then, marrow aspirate smears showed Toxoplasma gondii tachyzoites and pseudocyst. This case report alerts clinicians about Toxoplasma gondii infection in stem cell transplantation patients with multiple serous effusions and fever. Clinical trial: Not applicable.https://doi.org/10.1186/s12879-024-10249-8Toxoplasma gondiiStem cell transplantationMultiple serous effusionsSevere aplastic anemia |
| spellingShingle | Xiaoning Wang Hao Li Le Ma Juan Ren Fatahichegeni Mahsa Ansarian Mohammad Amin Jing Zhao Mei Zhang Pengcheng He Toxoplasmosis in a case with multiple serous effusions and severe aplastic anemia BMC Infectious Diseases Toxoplasma gondii Stem cell transplantation Multiple serous effusions Severe aplastic anemia |
| title | Toxoplasmosis in a case with multiple serous effusions and severe aplastic anemia |
| title_full | Toxoplasmosis in a case with multiple serous effusions and severe aplastic anemia |
| title_fullStr | Toxoplasmosis in a case with multiple serous effusions and severe aplastic anemia |
| title_full_unstemmed | Toxoplasmosis in a case with multiple serous effusions and severe aplastic anemia |
| title_short | Toxoplasmosis in a case with multiple serous effusions and severe aplastic anemia |
| title_sort | toxoplasmosis in a case with multiple serous effusions and severe aplastic anemia |
| topic | Toxoplasma gondii Stem cell transplantation Multiple serous effusions Severe aplastic anemia |
| url | https://doi.org/10.1186/s12879-024-10249-8 |
| work_keys_str_mv | AT xiaoningwang toxoplasmosisinacasewithmultipleserouseffusionsandsevereaplasticanemia AT haoli toxoplasmosisinacasewithmultipleserouseffusionsandsevereaplasticanemia AT lema toxoplasmosisinacasewithmultipleserouseffusionsandsevereaplasticanemia AT juanren toxoplasmosisinacasewithmultipleserouseffusionsandsevereaplasticanemia AT fatahichegenimahsa toxoplasmosisinacasewithmultipleserouseffusionsandsevereaplasticanemia AT ansarianmohammadamin toxoplasmosisinacasewithmultipleserouseffusionsandsevereaplasticanemia AT jingzhao toxoplasmosisinacasewithmultipleserouseffusionsandsevereaplasticanemia AT meizhang toxoplasmosisinacasewithmultipleserouseffusionsandsevereaplasticanemia AT pengchenghe toxoplasmosisinacasewithmultipleserouseffusionsandsevereaplasticanemia |