Metabolic reprogramming and immune microenvironment characteristics in laryngeal carcinoma: advances in immunotherapy
Laryngeal squamous cell carcinoma (LSCC) is a prevalent malignancy with high mortality and recurrence rates, necessitating novel therapeutic strategies. Recent research highlights the pivotal role of metabolic reprogramming and immune microenvironment alterations in LSCC pathogenesis, providing prom...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589243/full |
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| author | Kexin Ma Qingjie Mao Bing Fei Tingting Ni Zhenxin Zhang Haosheng Ni |
| author_facet | Kexin Ma Qingjie Mao Bing Fei Tingting Ni Zhenxin Zhang Haosheng Ni |
| author_sort | Kexin Ma |
| collection | DOAJ |
| description | Laryngeal squamous cell carcinoma (LSCC) is a prevalent malignancy with high mortality and recurrence rates, necessitating novel therapeutic strategies. Recent research highlights the pivotal role of metabolic reprogramming and immune microenvironment alterations in LSCC pathogenesis, providing promising avenues for targeted therapy. This review summarizes the metabolic characteristics of LSCC, including glycolysis, lipid metabolism, and amino acid biosynthesis, and their implications for tumor progression and therapeutic resistance. Additionally, this review further describes the tumor microenvironment’s immunosuppressive landscape, including immune checkpoint regulation, tumor-associated macrophages, and T-cell dysfunction. The integration of metabolic and immune-targeted strategies represents a promising frontier in LSCC treatment, warranting further investigation. |
| format | Article |
| id | doaj-art-f5ba11a9861a46a6bc671e3a2688af0c |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-f5ba11a9861a46a6bc671e3a2688af0c2025-08-20T03:53:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-04-011610.3389/fimmu.2025.15892431589243Metabolic reprogramming and immune microenvironment characteristics in laryngeal carcinoma: advances in immunotherapyKexin Ma0Qingjie Mao1Bing Fei2Tingting Ni3Zhenxin Zhang4Haosheng Ni5Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, ChinaDepartment of Otolaryngology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, ChinaDepartment of Otolaryngology Head and Neck Surgery, Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, ChinaDepartment of Oncology, Nantong Tumor Hospital, Nantong, ChinaDepartment of Otolaryngology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, ChinaDepartment of Otolaryngology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, ChinaLaryngeal squamous cell carcinoma (LSCC) is a prevalent malignancy with high mortality and recurrence rates, necessitating novel therapeutic strategies. Recent research highlights the pivotal role of metabolic reprogramming and immune microenvironment alterations in LSCC pathogenesis, providing promising avenues for targeted therapy. This review summarizes the metabolic characteristics of LSCC, including glycolysis, lipid metabolism, and amino acid biosynthesis, and their implications for tumor progression and therapeutic resistance. Additionally, this review further describes the tumor microenvironment’s immunosuppressive landscape, including immune checkpoint regulation, tumor-associated macrophages, and T-cell dysfunction. The integration of metabolic and immune-targeted strategies represents a promising frontier in LSCC treatment, warranting further investigation.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589243/fulllaryngeal squamous cell carcinomametabolic reprogrammingtumor microenvironmentimmune checkpoint inhibitorsglycolysisprecision medicine |
| spellingShingle | Kexin Ma Qingjie Mao Bing Fei Tingting Ni Zhenxin Zhang Haosheng Ni Metabolic reprogramming and immune microenvironment characteristics in laryngeal carcinoma: advances in immunotherapy Frontiers in Immunology laryngeal squamous cell carcinoma metabolic reprogramming tumor microenvironment immune checkpoint inhibitors glycolysis precision medicine |
| title | Metabolic reprogramming and immune microenvironment characteristics in laryngeal carcinoma: advances in immunotherapy |
| title_full | Metabolic reprogramming and immune microenvironment characteristics in laryngeal carcinoma: advances in immunotherapy |
| title_fullStr | Metabolic reprogramming and immune microenvironment characteristics in laryngeal carcinoma: advances in immunotherapy |
| title_full_unstemmed | Metabolic reprogramming and immune microenvironment characteristics in laryngeal carcinoma: advances in immunotherapy |
| title_short | Metabolic reprogramming and immune microenvironment characteristics in laryngeal carcinoma: advances in immunotherapy |
| title_sort | metabolic reprogramming and immune microenvironment characteristics in laryngeal carcinoma advances in immunotherapy |
| topic | laryngeal squamous cell carcinoma metabolic reprogramming tumor microenvironment immune checkpoint inhibitors glycolysis precision medicine |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589243/full |
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