The natural herbicide rhein targets photosystem I
Abstract The natural anthraquinone rhein has been identified as a novel herbicide with a potentially new mode of action using a generative AI system for functional molecules discovery. Its herbicidal activity was light-dependent and resulted in rapid burndown symptoms on leaves of treated plants. Rh...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-83891-6 |
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| author | Alyssa Twitty Hamlin Barnes Noa Levy Yaniv Mizrahi Yosef Geva Yael Phillip Franck E. Dayan |
| author_facet | Alyssa Twitty Hamlin Barnes Noa Levy Yaniv Mizrahi Yosef Geva Yael Phillip Franck E. Dayan |
| author_sort | Alyssa Twitty |
| collection | DOAJ |
| description | Abstract The natural anthraquinone rhein has been identified as a novel herbicide with a potentially new mode of action using a generative AI system for functional molecules discovery. Its herbicidal activity was light-dependent and resulted in rapid burndown symptoms on leaves of treated plants. Rhein interferes with photosynthesis by acting as an electron diverter at the level of photosystem I (PSI). The redox potential of rhein suggests that it accepts electrons between P700 and NADP+ of PSI. This is consistent with the redox potential of rhein that enables it to accept electrons from flavoproteins. Ferredoxin-NAPD+ reductase is a flavoprotein with a redox potential near that of rhein. Thus, it is currently hypothesized that rhein acts as an electron acceptor at or near the PSI Ferredoxin-NAPD+ reductase to form a radical and generate reactive oxygen species that drive the light-dependent herbicidal effect which is observed in treated plants from greenhouse trials. |
| format | Article |
| id | doaj-art-f5b538cea46e42fb8add9dfc3aff6c98 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-f5b538cea46e42fb8add9dfc3aff6c982025-01-05T12:30:34ZengNature PortfolioScientific Reports2045-23222024-12-0114111210.1038/s41598-024-83891-6The natural herbicide rhein targets photosystem IAlyssa Twitty0Hamlin Barnes1Noa Levy2Yaniv Mizrahi3Yosef Geva4Yael Phillip5Franck E. Dayan6Department of Agricultural Biology, Colorado State UniversityDepartment of Agricultural Biology, Colorado State UniversityAgrematch Ltd.Agrematch Ltd.Agrematch Ltd.Agrematch Ltd.Department of Agricultural Biology, Colorado State UniversityAbstract The natural anthraquinone rhein has been identified as a novel herbicide with a potentially new mode of action using a generative AI system for functional molecules discovery. Its herbicidal activity was light-dependent and resulted in rapid burndown symptoms on leaves of treated plants. Rhein interferes with photosynthesis by acting as an electron diverter at the level of photosystem I (PSI). The redox potential of rhein suggests that it accepts electrons between P700 and NADP+ of PSI. This is consistent with the redox potential of rhein that enables it to accept electrons from flavoproteins. Ferredoxin-NAPD+ reductase is a flavoprotein with a redox potential near that of rhein. Thus, it is currently hypothesized that rhein acts as an electron acceptor at or near the PSI Ferredoxin-NAPD+ reductase to form a radical and generate reactive oxygen species that drive the light-dependent herbicidal effect which is observed in treated plants from greenhouse trials.https://doi.org/10.1038/s41598-024-83891-6AIArtificial intelligenceGenerative AIMode of actionPhotosystem IAnthraquinone |
| spellingShingle | Alyssa Twitty Hamlin Barnes Noa Levy Yaniv Mizrahi Yosef Geva Yael Phillip Franck E. Dayan The natural herbicide rhein targets photosystem I Scientific Reports AI Artificial intelligence Generative AI Mode of action Photosystem I Anthraquinone |
| title | The natural herbicide rhein targets photosystem I |
| title_full | The natural herbicide rhein targets photosystem I |
| title_fullStr | The natural herbicide rhein targets photosystem I |
| title_full_unstemmed | The natural herbicide rhein targets photosystem I |
| title_short | The natural herbicide rhein targets photosystem I |
| title_sort | natural herbicide rhein targets photosystem i |
| topic | AI Artificial intelligence Generative AI Mode of action Photosystem I Anthraquinone |
| url | https://doi.org/10.1038/s41598-024-83891-6 |
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