Fungal Biofilm Resistance
Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required. This places a large financial burden on health...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | International Journal of Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2012/528521 |
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| _version_ | 1841524816237035520 |
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| author | Gordon Ramage Ranjith Rajendran Leighann Sherry Craig Williams |
| author_facet | Gordon Ramage Ranjith Rajendran Leighann Sherry Craig Williams |
| author_sort | Gordon Ramage |
| collection | DOAJ |
| description | Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required. This places a large financial burden on health care providers. This paper aims to illustrate the importance of fungal biofilms, particularly Candida albicans, and discusses some of the key fungal biofilm resistance mechanisms that include, extracellular matrix (ECM), efflux pump activity, persisters, cell density, overexpression of drug targets, stress responses, and the general physiology of the cell. The paper demonstrates the multifaceted nature of fungal biofilm resistance, which encompasses some of the newest data and ideas in the field. |
| format | Article |
| id | doaj-art-f59584a850c64ef0a449aa35c2e968f9 |
| institution | Kabale University |
| issn | 1687-918X 1687-9198 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Microbiology |
| spelling | doaj-art-f59584a850c64ef0a449aa35c2e968f92025-02-03T05:47:23ZengWileyInternational Journal of Microbiology1687-918X1687-91982012-01-01201210.1155/2012/528521528521Fungal Biofilm ResistanceGordon Ramage0Ranjith Rajendran1Leighann Sherry2Craig Williams3Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G2 3JZ, UKGlasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G2 3JZ, UKGlasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G2 3JZ, UKMicrobiology Department, Royal Hospital for Sick Children (Yorkhill Division), Dalnair Street, Glasgow G3 8SJ, UKFungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required. This places a large financial burden on health care providers. This paper aims to illustrate the importance of fungal biofilms, particularly Candida albicans, and discusses some of the key fungal biofilm resistance mechanisms that include, extracellular matrix (ECM), efflux pump activity, persisters, cell density, overexpression of drug targets, stress responses, and the general physiology of the cell. The paper demonstrates the multifaceted nature of fungal biofilm resistance, which encompasses some of the newest data and ideas in the field.http://dx.doi.org/10.1155/2012/528521 |
| spellingShingle | Gordon Ramage Ranjith Rajendran Leighann Sherry Craig Williams Fungal Biofilm Resistance International Journal of Microbiology |
| title | Fungal Biofilm Resistance |
| title_full | Fungal Biofilm Resistance |
| title_fullStr | Fungal Biofilm Resistance |
| title_full_unstemmed | Fungal Biofilm Resistance |
| title_short | Fungal Biofilm Resistance |
| title_sort | fungal biofilm resistance |
| url | http://dx.doi.org/10.1155/2012/528521 |
| work_keys_str_mv | AT gordonramage fungalbiofilmresistance AT ranjithrajendran fungalbiofilmresistance AT leighannsherry fungalbiofilmresistance AT craigwilliams fungalbiofilmresistance |