Neurosteroid Binding Sites on the GABAA Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence
Despite the prevalence of alcohol abuse and dependence in the US and Europe, there are only five approved pharmacotherapies for alcohol dependence. Moreover, these pharmacotherapeutic options have limited clinical utility. The purpose of this paper is to present pertinent literature suggesting that...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2011/926361 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841524594208407552 |
|---|---|
| author | Mary W. Hulin Russell J. Amato Johnny R. Porter Catalin M. Filipeanu Peter J. Winsauer |
| author_facet | Mary W. Hulin Russell J. Amato Johnny R. Porter Catalin M. Filipeanu Peter J. Winsauer |
| author_sort | Mary W. Hulin |
| collection | DOAJ |
| description | Despite the prevalence of alcohol abuse and dependence in the US and Europe, there are only five approved pharmacotherapies for alcohol dependence. Moreover, these pharmacotherapeutic options have limited clinical utility. The purpose of this paper is to present pertinent literature suggesting that both alcohol and the neurosteroids interact at the GABAA receptor complex and that the neurosteroid sites on this receptor complex could serve as new targets for the development of novel therapeutics for alcohol abuse. This paper will also present data collected by our laboratory showing that one neurosteroid in particular, dehydroepiandrosterone (DHEA), decreases ethanol intake in rats under a variety of conditions. In the process, we will also mention relevant studies from the literature suggesting that both particular subtypes and subunits of the GABAA receptor play an important role in mediating the interaction of neurosteroids and ethanol. |
| format | Article |
| id | doaj-art-f58b6d7a5d8c444fb1cb5412341dda07 |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-f58b6d7a5d8c444fb1cb5412341dda072025-02-03T05:47:57ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422011-01-01201110.1155/2011/926361926361Neurosteroid Binding Sites on the GABAA Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and DependenceMary W. Hulin0Russell J. Amato1Johnny R. Porter2Catalin M. Filipeanu3Peter J. Winsauer4Department of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112-1393, USADepartment of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112-1393, USADepartment of Physiology, LSU Health Sciences Center, New Orleans, LA 70112-1393, USADepartment of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112-1393, USADepartment of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, 1901 Perdido Street, New Orleans, LA 70112-1393, USADespite the prevalence of alcohol abuse and dependence in the US and Europe, there are only five approved pharmacotherapies for alcohol dependence. Moreover, these pharmacotherapeutic options have limited clinical utility. The purpose of this paper is to present pertinent literature suggesting that both alcohol and the neurosteroids interact at the GABAA receptor complex and that the neurosteroid sites on this receptor complex could serve as new targets for the development of novel therapeutics for alcohol abuse. This paper will also present data collected by our laboratory showing that one neurosteroid in particular, dehydroepiandrosterone (DHEA), decreases ethanol intake in rats under a variety of conditions. In the process, we will also mention relevant studies from the literature suggesting that both particular subtypes and subunits of the GABAA receptor play an important role in mediating the interaction of neurosteroids and ethanol.http://dx.doi.org/10.1155/2011/926361 |
| spellingShingle | Mary W. Hulin Russell J. Amato Johnny R. Porter Catalin M. Filipeanu Peter J. Winsauer Neurosteroid Binding Sites on the GABAA Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence Advances in Pharmacological Sciences |
| title | Neurosteroid Binding Sites on the GABAA Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence |
| title_full | Neurosteroid Binding Sites on the GABAA Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence |
| title_fullStr | Neurosteroid Binding Sites on the GABAA Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence |
| title_full_unstemmed | Neurosteroid Binding Sites on the GABAA Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence |
| title_short | Neurosteroid Binding Sites on the GABAA Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence |
| title_sort | neurosteroid binding sites on the gabaa receptor complex as novel targets for therapeutics to reduce alcohol abuse and dependence |
| url | http://dx.doi.org/10.1155/2011/926361 |
| work_keys_str_mv | AT marywhulin neurosteroidbindingsitesonthegabaareceptorcomplexasnoveltargetsfortherapeuticstoreducealcoholabuseanddependence AT russelljamato neurosteroidbindingsitesonthegabaareceptorcomplexasnoveltargetsfortherapeuticstoreducealcoholabuseanddependence AT johnnyrporter neurosteroidbindingsitesonthegabaareceptorcomplexasnoveltargetsfortherapeuticstoreducealcoholabuseanddependence AT catalinmfilipeanu neurosteroidbindingsitesonthegabaareceptorcomplexasnoveltargetsfortherapeuticstoreducealcoholabuseanddependence AT peterjwinsauer neurosteroidbindingsitesonthegabaareceptorcomplexasnoveltargetsfortherapeuticstoreducealcoholabuseanddependence |