Correlation of serum chloride concentrations with components of the renin‐angiotensin‐aldosterone system in a dog with congestive heart failure
Abstract A 7‐year‐old male castrated Cavalier King Charles Spaniel was hospitalized for 12 days for treatment of severe congestive heart failure secondary to myxomatous mitral valve disease. During that time, 6 serum samples from different days were analyzed for serum biochemical and renin‐angiotens...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Journal of Veterinary Internal Medicine |
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| Online Access: | https://doi.org/10.1111/jvim.17238 |
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| author | Cailey Banken Autumn N. Harris Rachel Conway Eduardo J. Benjamin Robin Shoemaker Darcy Adin |
| author_facet | Cailey Banken Autumn N. Harris Rachel Conway Eduardo J. Benjamin Robin Shoemaker Darcy Adin |
| author_sort | Cailey Banken |
| collection | DOAJ |
| description | Abstract A 7‐year‐old male castrated Cavalier King Charles Spaniel was hospitalized for 12 days for treatment of severe congestive heart failure secondary to myxomatous mitral valve disease. During that time, 6 serum samples from different days were analyzed for serum biochemical and renin‐angiotensin‐aldosterone system components. Serum chloride concentrations (ranging from 71.6 to 103.1 mmol/L) were inversely related to angiotensin I concentrations, aldosterone concentrations, a surrogate marker of renin activity, and a surrogate marker of adrenal responsiveness to angiotensin II. In light of recent studies showing that hypochloremia is associated with advanced heart failure in dogs and is associated with poor outcomes in people, the information from the dog in this report supports exploration of RAAS dysregulation as an underlying mechanism. |
| format | Article |
| id | doaj-art-f58a85296b1249ad83669b0847734ba6 |
| institution | Kabale University |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-f58a85296b1249ad83669b0847734ba62024-11-25T08:31:40ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762024-11-013863255326010.1111/jvim.17238Correlation of serum chloride concentrations with components of the renin‐angiotensin‐aldosterone system in a dog with congestive heart failureCailey Banken0Autumn N. Harris1Rachel Conway2Eduardo J. Benjamin3Robin Shoemaker4Darcy Adin5Department of Small Animal Clinical Sciences, College of Veterinary Medicine University of Florida Gainesville Florida USADepartment of Small Animal Clinical Sciences, College of Veterinary Medicine University of Florida Gainesville Florida USADepartment of Small Animal Clinical Sciences, College of Veterinary Medicine University of Florida Gainesville Florida USADepartment of Small Animal Clinical Sciences, College of Veterinary Medicine University of Florida Gainesville Florida USADepartment of Pediatrics, College of Medicine University of Kentucky Lexington Kentucky USADepartment of Small Animal Clinical Sciences, College of Veterinary Medicine University of Florida Gainesville Florida USAAbstract A 7‐year‐old male castrated Cavalier King Charles Spaniel was hospitalized for 12 days for treatment of severe congestive heart failure secondary to myxomatous mitral valve disease. During that time, 6 serum samples from different days were analyzed for serum biochemical and renin‐angiotensin‐aldosterone system components. Serum chloride concentrations (ranging from 71.6 to 103.1 mmol/L) were inversely related to angiotensin I concentrations, aldosterone concentrations, a surrogate marker of renin activity, and a surrogate marker of adrenal responsiveness to angiotensin II. In light of recent studies showing that hypochloremia is associated with advanced heart failure in dogs and is associated with poor outcomes in people, the information from the dog in this report supports exploration of RAAS dysregulation as an underlying mechanism.https://doi.org/10.1111/jvim.17238diureticselectrolyteshypochloremiaRAAS |
| spellingShingle | Cailey Banken Autumn N. Harris Rachel Conway Eduardo J. Benjamin Robin Shoemaker Darcy Adin Correlation of serum chloride concentrations with components of the renin‐angiotensin‐aldosterone system in a dog with congestive heart failure Journal of Veterinary Internal Medicine diuretics electrolytes hypochloremia RAAS |
| title | Correlation of serum chloride concentrations with components of the renin‐angiotensin‐aldosterone system in a dog with congestive heart failure |
| title_full | Correlation of serum chloride concentrations with components of the renin‐angiotensin‐aldosterone system in a dog with congestive heart failure |
| title_fullStr | Correlation of serum chloride concentrations with components of the renin‐angiotensin‐aldosterone system in a dog with congestive heart failure |
| title_full_unstemmed | Correlation of serum chloride concentrations with components of the renin‐angiotensin‐aldosterone system in a dog with congestive heart failure |
| title_short | Correlation of serum chloride concentrations with components of the renin‐angiotensin‐aldosterone system in a dog with congestive heart failure |
| title_sort | correlation of serum chloride concentrations with components of the renin angiotensin aldosterone system in a dog with congestive heart failure |
| topic | diuretics electrolytes hypochloremia RAAS |
| url | https://doi.org/10.1111/jvim.17238 |
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