Melittin as a therapeutic agent for rheumatoid arthritis: mechanistic insights, advanced delivery systems, and future perspectives
Rheumatoid arthritis (RA), a condition characterized by joint deterioration through the action of matrix metalloproteinases (MMPs), is prevalent worldwide. Bee venom (BV) has traditionally been used in Chinese medicine for pain, arthritis, rheumatism, skin diseases, etc. BV is enriched with active s...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-12-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1510693/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846114921679421440 |
|---|---|
| author | Ashutosh Pareek Khushbu Mehlawat Kritika Tripathi Aaushi Pareek Simran Chaudhary Yashumati Ratan Vasso Apostolopoulos Anil Chuturgoon |
| author_facet | Ashutosh Pareek Khushbu Mehlawat Kritika Tripathi Aaushi Pareek Simran Chaudhary Yashumati Ratan Vasso Apostolopoulos Anil Chuturgoon |
| author_sort | Ashutosh Pareek |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA), a condition characterized by joint deterioration through the action of matrix metalloproteinases (MMPs), is prevalent worldwide. Bee venom (BV) has traditionally been used in Chinese medicine for pain, arthritis, rheumatism, skin diseases, etc. BV is enriched with active substances, notably melittin and phospholipase A2 (PLA2), offering significant therapeutic potential. Hence, the review summarizes current insights into BV’s composition, antiarthritic mechanism and pharmacological benefits, focusing on melittin. Constituting 50-60% of BV, melittin notably downregulates nuclear factor Kappa B (NF-κB) activity, inhibits MMP-1 and MMP-8, and diminishes tumor necrosis factor (TNF-α), all of which contribute to the mitigation of type 2 collagen degradation. Despite its potential, melittin exhibits hemolytic activity and can significantly affect cell membranes, limiting its application, which poses a challenge to its therapeutic use. To overcome these challenges, delivery techniques utilizing nanocarriers and modifications in amino acid sequencing have been developed. Recent advancements in delivery systems, including nanocarriers, transdermal patches, and nanoemulsions, aim to minimize toxicity, expanding its therapeutic utility for RA. This article explores these novel strategies, underlining the evolving role of melittin in RA management. |
| format | Article |
| id | doaj-art-f5888a03b65a4dc895d0131fa806d8f3 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-f5888a03b65a4dc895d0131fa806d8f32024-12-20T06:29:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.15106931510693Melittin as a therapeutic agent for rheumatoid arthritis: mechanistic insights, advanced delivery systems, and future perspectivesAshutosh Pareek0Khushbu Mehlawat1Kritika Tripathi2Aaushi Pareek3Simran Chaudhary4Yashumati Ratan5Vasso Apostolopoulos6Anil Chuturgoon7Department of Pharmacy, Banasthali Vidyapith, Banasthali, IndiaDepartment of Pharmacy, Banasthali Vidyapith, Banasthali, IndiaDepartment of Pharmacy, Banasthali Vidyapith, Banasthali, IndiaDepartment of Pharmacy, Banasthali Vidyapith, Banasthali, IndiaDepartment of Pharmacy, Banasthali Vidyapith, Banasthali, IndiaDepartment of Pharmacy, Banasthali Vidyapith, Banasthali, IndiaSchool of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, AustraliaDiscipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South AfricaRheumatoid arthritis (RA), a condition characterized by joint deterioration through the action of matrix metalloproteinases (MMPs), is prevalent worldwide. Bee venom (BV) has traditionally been used in Chinese medicine for pain, arthritis, rheumatism, skin diseases, etc. BV is enriched with active substances, notably melittin and phospholipase A2 (PLA2), offering significant therapeutic potential. Hence, the review summarizes current insights into BV’s composition, antiarthritic mechanism and pharmacological benefits, focusing on melittin. Constituting 50-60% of BV, melittin notably downregulates nuclear factor Kappa B (NF-κB) activity, inhibits MMP-1 and MMP-8, and diminishes tumor necrosis factor (TNF-α), all of which contribute to the mitigation of type 2 collagen degradation. Despite its potential, melittin exhibits hemolytic activity and can significantly affect cell membranes, limiting its application, which poses a challenge to its therapeutic use. To overcome these challenges, delivery techniques utilizing nanocarriers and modifications in amino acid sequencing have been developed. Recent advancements in delivery systems, including nanocarriers, transdermal patches, and nanoemulsions, aim to minimize toxicity, expanding its therapeutic utility for RA. This article explores these novel strategies, underlining the evolving role of melittin in RA management.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1510693/fullrheumatoid arthritisbee venommelittinanti-inflammatorynovel formulations |
| spellingShingle | Ashutosh Pareek Khushbu Mehlawat Kritika Tripathi Aaushi Pareek Simran Chaudhary Yashumati Ratan Vasso Apostolopoulos Anil Chuturgoon Melittin as a therapeutic agent for rheumatoid arthritis: mechanistic insights, advanced delivery systems, and future perspectives Frontiers in Immunology rheumatoid arthritis bee venom melittin anti-inflammatory novel formulations |
| title | Melittin as a therapeutic agent for rheumatoid arthritis: mechanistic insights, advanced delivery systems, and future perspectives |
| title_full | Melittin as a therapeutic agent for rheumatoid arthritis: mechanistic insights, advanced delivery systems, and future perspectives |
| title_fullStr | Melittin as a therapeutic agent for rheumatoid arthritis: mechanistic insights, advanced delivery systems, and future perspectives |
| title_full_unstemmed | Melittin as a therapeutic agent for rheumatoid arthritis: mechanistic insights, advanced delivery systems, and future perspectives |
| title_short | Melittin as a therapeutic agent for rheumatoid arthritis: mechanistic insights, advanced delivery systems, and future perspectives |
| title_sort | melittin as a therapeutic agent for rheumatoid arthritis mechanistic insights advanced delivery systems and future perspectives |
| topic | rheumatoid arthritis bee venom melittin anti-inflammatory novel formulations |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1510693/full |
| work_keys_str_mv | AT ashutoshpareek melittinasatherapeuticagentforrheumatoidarthritismechanisticinsightsadvanceddeliverysystemsandfutureperspectives AT khushbumehlawat melittinasatherapeuticagentforrheumatoidarthritismechanisticinsightsadvanceddeliverysystemsandfutureperspectives AT kritikatripathi melittinasatherapeuticagentforrheumatoidarthritismechanisticinsightsadvanceddeliverysystemsandfutureperspectives AT aaushipareek melittinasatherapeuticagentforrheumatoidarthritismechanisticinsightsadvanceddeliverysystemsandfutureperspectives AT simranchaudhary melittinasatherapeuticagentforrheumatoidarthritismechanisticinsightsadvanceddeliverysystemsandfutureperspectives AT yashumatiratan melittinasatherapeuticagentforrheumatoidarthritismechanisticinsightsadvanceddeliverysystemsandfutureperspectives AT vassoapostolopoulos melittinasatherapeuticagentforrheumatoidarthritismechanisticinsightsadvanceddeliverysystemsandfutureperspectives AT anilchuturgoon melittinasatherapeuticagentforrheumatoidarthritismechanisticinsightsadvanceddeliverysystemsandfutureperspectives |