Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma

Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma

Chimeric antigen receptor T-cell (CAR-T) therapies have shown promise in glioblastoma clinical studies, but responses remain inconsistent due to heterogeneous tumor antigen expression and immune evasion post-treatment. NKG2D CAR-T cells have demonstrated a favorable safety profile in patients with h...

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Bibliographic Details
Main Authors: Junchen Liu, Kun Dai, Muhammad Auwal Saliu, Mansur Dabai Salisu, Jiangyu Gan, Lukman Olalekan Afolabi, Dehong Yan, Guizhong Zhang, Maoxuan Liu, Xiaochun Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
CAR-T
glioblastoma
NKG2D
sodium valproate
combination therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1519777/full
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