SARS-CoV-2 coinfections among pertussis cases identified through the Enhanced Pertussis Surveillance system in the United States, January 2020-February 2023.
<h4>Background</h4>Bacterial and viral respiratory coinfections are common, but the prevalence of SARS-CoV-2 infections among pertussis cases has not been estimated. We examine the prevalence and temporality of SARS-CoV-2 infections among pertussis patients and describe pertussis clinica...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0311488 |
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| author | Isha Berry Matthew Cole Benjamin Silk Fiona P Havers Erin Youngkin Adam Misiorski Samantha Sefton Yeng Vang Emma Stanislawski Suzanne McGuire Noel Silhan Tami H Skoff Amy B Rubis |
| author_facet | Isha Berry Matthew Cole Benjamin Silk Fiona P Havers Erin Youngkin Adam Misiorski Samantha Sefton Yeng Vang Emma Stanislawski Suzanne McGuire Noel Silhan Tami H Skoff Amy B Rubis |
| author_sort | Isha Berry |
| collection | DOAJ |
| description | <h4>Background</h4>Bacterial and viral respiratory coinfections are common, but the prevalence of SARS-CoV-2 infections among pertussis cases has not been estimated. We examine the prevalence and temporality of SARS-CoV-2 infections among pertussis patients and describe pertussis clinical severity among patients with and without SARS-CoV-2 coinfections.<h4>Methods</h4>Confirmed and probable pertussis cases among individuals with cough onset between January 1, 2020 and February 15, 2023 were identified through surveillance in seven Enhanced Pertussis Surveillance (EPS) sites. Pertussis cases with a laboratory-confirmed SARS-CoV-2 infection detected within 30 days before or after pertussis cough onset were defined as coinfections. We describe patient demographics, symptoms, and severe complications and outcomes (seizures, encephalopathy, pneumonia, hospitalization, or death) by coinfection status.<h4>Results</h4>Among 765 pertussis cases reported during the study period, the prevalence of SARS-CoV-2 coinfections was 0.78% [6/765]. Among the six patients meeting the coinfection definition, the majority (83.3% [5/6]) had SARS-CoV-2 infections detected following pertussis cough onset. Compared to those with no known coinfection, a higher proportion of those with coinfections reported severe complications or outcomes (50.0% [3/6] vs. 5.2% [36/694]).<h4>Discussion</h4>Although the prevalence of pertussis patients with SARS-CoV-2 coinfections was low, patients with coinfections reported more severe complications and outcomes compared to those with pertussis alone. Given the decline in reported pertussis cases during the COVID-19 pandemic, continued monitoring of pertussis incidence alongside respiratory viral infections will be important as the pertussis burden returns to pre-pandemic levels. |
| format | Article |
| id | doaj-art-f5734fcdf3d5478c8876be5570c5c173 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-f5734fcdf3d5478c8876be5570c5c1732024-12-10T05:32:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031148810.1371/journal.pone.0311488SARS-CoV-2 coinfections among pertussis cases identified through the Enhanced Pertussis Surveillance system in the United States, January 2020-February 2023.Isha BerryMatthew ColeBenjamin SilkFiona P HaversErin YoungkinAdam MisiorskiSamantha SeftonYeng VangEmma StanislawskiSuzanne McGuireNoel SilhanTami H SkoffAmy B Rubis<h4>Background</h4>Bacterial and viral respiratory coinfections are common, but the prevalence of SARS-CoV-2 infections among pertussis cases has not been estimated. We examine the prevalence and temporality of SARS-CoV-2 infections among pertussis patients and describe pertussis clinical severity among patients with and without SARS-CoV-2 coinfections.<h4>Methods</h4>Confirmed and probable pertussis cases among individuals with cough onset between January 1, 2020 and February 15, 2023 were identified through surveillance in seven Enhanced Pertussis Surveillance (EPS) sites. Pertussis cases with a laboratory-confirmed SARS-CoV-2 infection detected within 30 days before or after pertussis cough onset were defined as coinfections. We describe patient demographics, symptoms, and severe complications and outcomes (seizures, encephalopathy, pneumonia, hospitalization, or death) by coinfection status.<h4>Results</h4>Among 765 pertussis cases reported during the study period, the prevalence of SARS-CoV-2 coinfections was 0.78% [6/765]. Among the six patients meeting the coinfection definition, the majority (83.3% [5/6]) had SARS-CoV-2 infections detected following pertussis cough onset. Compared to those with no known coinfection, a higher proportion of those with coinfections reported severe complications or outcomes (50.0% [3/6] vs. 5.2% [36/694]).<h4>Discussion</h4>Although the prevalence of pertussis patients with SARS-CoV-2 coinfections was low, patients with coinfections reported more severe complications and outcomes compared to those with pertussis alone. Given the decline in reported pertussis cases during the COVID-19 pandemic, continued monitoring of pertussis incidence alongside respiratory viral infections will be important as the pertussis burden returns to pre-pandemic levels.https://doi.org/10.1371/journal.pone.0311488 |
| spellingShingle | Isha Berry Matthew Cole Benjamin Silk Fiona P Havers Erin Youngkin Adam Misiorski Samantha Sefton Yeng Vang Emma Stanislawski Suzanne McGuire Noel Silhan Tami H Skoff Amy B Rubis SARS-CoV-2 coinfections among pertussis cases identified through the Enhanced Pertussis Surveillance system in the United States, January 2020-February 2023. PLoS ONE |
| title | SARS-CoV-2 coinfections among pertussis cases identified through the Enhanced Pertussis Surveillance system in the United States, January 2020-February 2023. |
| title_full | SARS-CoV-2 coinfections among pertussis cases identified through the Enhanced Pertussis Surveillance system in the United States, January 2020-February 2023. |
| title_fullStr | SARS-CoV-2 coinfections among pertussis cases identified through the Enhanced Pertussis Surveillance system in the United States, January 2020-February 2023. |
| title_full_unstemmed | SARS-CoV-2 coinfections among pertussis cases identified through the Enhanced Pertussis Surveillance system in the United States, January 2020-February 2023. |
| title_short | SARS-CoV-2 coinfections among pertussis cases identified through the Enhanced Pertussis Surveillance system in the United States, January 2020-February 2023. |
| title_sort | sars cov 2 coinfections among pertussis cases identified through the enhanced pertussis surveillance system in the united states january 2020 february 2023 |
| url | https://doi.org/10.1371/journal.pone.0311488 |
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