Predictive Value of Resistin in Acute Coronary Syndrome Patients with and without Type 2 Diabetes Mellitus
Background: Resistin in humans is classified as an adipokine and has been proposed as an inflammatory marker, associated with the development of atherosclerosis and coronary artery disease.Objectives: To evaluate serum resistin levels in patients with acute coronary syndrome (ACS) with and without t...
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University of Anbar
2024-12-01
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| Series: | Al-Anbar Medical Journal |
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| Online Access: | https://amj.uoanbar.edu.iq/article_184028_0cf8e4364567e9405268e6faffda8968.pdf |
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| author | Istabraq shehap Hazim Ghazzay Khalid Abdulghafoor |
| author_facet | Istabraq shehap Hazim Ghazzay Khalid Abdulghafoor |
| author_sort | Istabraq shehap |
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| description | Background: Resistin in humans is classified as an adipokine and has been proposed as an inflammatory marker, associated with the development of atherosclerosis and coronary artery disease.Objectives: To evaluate serum resistin levels in patients with acute coronary syndrome (ACS) with and without type 2 diabetes mellitus (T2DM). In addition, correlating serum resistin with clinical and biochemical parameters was another objective.Materials and Methods: This study included 60 patients with ACS diagnoses. The participants were categorized into two groups: 30 patients with both ACS and T2DM and 30 patients with ACS but without T2DM. The control group comprised 30 healthy individuals who matched the patient groups regarding sex and age. Levels of serum lipids, fasting blood glucose (FBG), Hemoglobin A1c (HbA1c), C-reactive protein (CRP), troponin I, and resistin, were estimated for each participant.Results: The levels of resistin in the serum were significantly higher in ACS with T2DM or ACS without T2DM patients compared to healthy individuals (1.184 ± 0.271 ng/mL and 1.249 ± 0.358 vs. 0.601 ± 0.141 ng/mL, respectively, P-value = 0.001). The analysis of the data exhibited a significant positive correlation between serum resistin and CRP levels in the ACS with T2DM (r = 0.412; P-value = 0.018) and the ACS without T2DM (r = 0.467; P-value = 0.01). There was no significant correlation between serum resistin levels and other variables in these two groups. The receiver operating characteristic (ROC) analysis in ACS with T2DM exhibited that serum resistin level larger than 0.896 ng/mL was correlated with an elevated incidence of ACS (Area Under the Curve = 0.988, sensitivity = 93.33%, specificity = 93.33%, and likelihood ratio = 14). In contrast, ROC analysis in ACS without T2DM exhibited that a serum resistin level greater than 0.830 ng/mL was correlated with an elevated incidence of ACS (Area Under the Curve = 0.978, sensitivity = 90%, specificity = 90%, and likelihood ratio = 9). Conclusion: Serum resistin can be used to predict ACS in patients with or without T2DM. Also, resistin is an effector molecule of the inflammatory response that contributes to ACS. |
| format | Article |
| id | doaj-art-f564147d527b4ea2a75b9f3be590efa8 |
| institution | Kabale University |
| issn | 2706-6207 2664-3154 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | University of Anbar |
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| series | Al-Anbar Medical Journal |
| spelling | doaj-art-f564147d527b4ea2a75b9f3be590efa82024-12-01T20:14:36ZengUniversity of AnbarAl-Anbar Medical Journal2706-62072664-31542024-12-0120214415010.33091/amj.2024.148512.1654184028Predictive Value of Resistin in Acute Coronary Syndrome Patients with and without Type 2 Diabetes MellitusIstabraq shehap0Hazim Ghazzay1Khalid Abdulghafoor2Department of Chemistry, College of Science, University of Anbar, Anbar, Iraq.Department of Internal Medicine, College of Medicine, University of Anbar, Anbar, Iraq.Department of Chemistry, College of Science, University of Anbar, Anbar, Iraq.Background: Resistin in humans is classified as an adipokine and has been proposed as an inflammatory marker, associated with the development of atherosclerosis and coronary artery disease.Objectives: To evaluate serum resistin levels in patients with acute coronary syndrome (ACS) with and without type 2 diabetes mellitus (T2DM). In addition, correlating serum resistin with clinical and biochemical parameters was another objective.Materials and Methods: This study included 60 patients with ACS diagnoses. The participants were categorized into two groups: 30 patients with both ACS and T2DM and 30 patients with ACS but without T2DM. The control group comprised 30 healthy individuals who matched the patient groups regarding sex and age. Levels of serum lipids, fasting blood glucose (FBG), Hemoglobin A1c (HbA1c), C-reactive protein (CRP), troponin I, and resistin, were estimated for each participant.Results: The levels of resistin in the serum were significantly higher in ACS with T2DM or ACS without T2DM patients compared to healthy individuals (1.184 ± 0.271 ng/mL and 1.249 ± 0.358 vs. 0.601 ± 0.141 ng/mL, respectively, P-value = 0.001). The analysis of the data exhibited a significant positive correlation between serum resistin and CRP levels in the ACS with T2DM (r = 0.412; P-value = 0.018) and the ACS without T2DM (r = 0.467; P-value = 0.01). There was no significant correlation between serum resistin levels and other variables in these two groups. The receiver operating characteristic (ROC) analysis in ACS with T2DM exhibited that serum resistin level larger than 0.896 ng/mL was correlated with an elevated incidence of ACS (Area Under the Curve = 0.988, sensitivity = 93.33%, specificity = 93.33%, and likelihood ratio = 14). In contrast, ROC analysis in ACS without T2DM exhibited that a serum resistin level greater than 0.830 ng/mL was correlated with an elevated incidence of ACS (Area Under the Curve = 0.978, sensitivity = 90%, specificity = 90%, and likelihood ratio = 9). Conclusion: Serum resistin can be used to predict ACS in patients with or without T2DM. Also, resistin is an effector molecule of the inflammatory response that contributes to ACS.https://amj.uoanbar.edu.iq/article_184028_0cf8e4364567e9405268e6faffda8968.pdfresistinacute coronary syndrometype 2 diabetes mellitus |
| spellingShingle | Istabraq shehap Hazim Ghazzay Khalid Abdulghafoor Predictive Value of Resistin in Acute Coronary Syndrome Patients with and without Type 2 Diabetes Mellitus Al-Anbar Medical Journal resistin acute coronary syndrome type 2 diabetes mellitus |
| title | Predictive Value of Resistin in Acute Coronary Syndrome Patients with and without Type 2 Diabetes Mellitus |
| title_full | Predictive Value of Resistin in Acute Coronary Syndrome Patients with and without Type 2 Diabetes Mellitus |
| title_fullStr | Predictive Value of Resistin in Acute Coronary Syndrome Patients with and without Type 2 Diabetes Mellitus |
| title_full_unstemmed | Predictive Value of Resistin in Acute Coronary Syndrome Patients with and without Type 2 Diabetes Mellitus |
| title_short | Predictive Value of Resistin in Acute Coronary Syndrome Patients with and without Type 2 Diabetes Mellitus |
| title_sort | predictive value of resistin in acute coronary syndrome patients with and without type 2 diabetes mellitus |
| topic | resistin acute coronary syndrome type 2 diabetes mellitus |
| url | https://amj.uoanbar.edu.iq/article_184028_0cf8e4364567e9405268e6faffda8968.pdf |
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