Measures of Bacterial Endotoxins in Gingival Crevicular Fluid and Peripheral Blood of Aggressive Periodontitis Cases—A Clinical Association
Introduction: The present study was undertaken with the objective to evaluate the level of endotoxin produced in the gingival crevicular fluid (GCF) and peripheral blood of subjects with generalized aggressive periodontitis (GAgP) in comparison with periodontally healthy subjects at baseline, three...
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1064_24 |
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| author | Akanksha Kashyap Brijendra Singh Srishti Shankar Atul Gupta Piyush Gowrav Mohammad Arif Khan |
| author_facet | Akanksha Kashyap Brijendra Singh Srishti Shankar Atul Gupta Piyush Gowrav Mohammad Arif Khan |
| author_sort | Akanksha Kashyap |
| collection | DOAJ |
| description | Introduction:
The present study was undertaken with the objective to evaluate the level of endotoxin produced in the gingival crevicular fluid (GCF) and peripheral blood of subjects with generalized aggressive periodontitis (GAgP) in comparison with periodontally healthy subjects at baseline, three months, and six months post-periodontal surgical treatment.
Materials and Methods:
A total of 24 subjects aged between 20 and 50 years were selected for the study. They were divided into two groups: generalized aggressive periodontitis (GAgP) subjects (Group A) and periodontally and systemically healthy individuals (Group B). Endotoxin levels were assessed in GCF and peripheral blood of both the groups at baseline, three months, and six months postsurgical treatment. The clinical parameters, such as plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL), were also recorded at same time intervals. A correlation between the clinical parameters and endotoxin in GCF and peripheral blood was established in diseased cases as compared to healthy individuals.
Results:
Favorable clinical outcomes with the reduction of PI, GI, PPD, and CAL were achieved for Group A post-surgery when compared to baseline. The GCF endotoxin level in Group A was observed to be significantly higher than Group B and reduced favorably after treatment. In peripheral blood, there was no significant difference in endotoxin level between both the groups.
Conclusion:
It can be concluded from the results that the level of bacterial endotoxin was significantly raised in GCF, indicating its role in the causation of rapid destruction of the periodontium in aggressive periodontitis subjects. |
| format | Article |
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| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-f550e9adeb894163aed3b79f3e7911a92025-01-13T10:17:21ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S3715S371710.4103/jpbs.jpbs_1064_24Measures of Bacterial Endotoxins in Gingival Crevicular Fluid and Peripheral Blood of Aggressive Periodontitis Cases—A Clinical AssociationAkanksha KashyapBrijendra SinghSrishti ShankarAtul GuptaPiyush GowravMohammad Arif KhanIntroduction: The present study was undertaken with the objective to evaluate the level of endotoxin produced in the gingival crevicular fluid (GCF) and peripheral blood of subjects with generalized aggressive periodontitis (GAgP) in comparison with periodontally healthy subjects at baseline, three months, and six months post-periodontal surgical treatment. Materials and Methods: A total of 24 subjects aged between 20 and 50 years were selected for the study. They were divided into two groups: generalized aggressive periodontitis (GAgP) subjects (Group A) and periodontally and systemically healthy individuals (Group B). Endotoxin levels were assessed in GCF and peripheral blood of both the groups at baseline, three months, and six months postsurgical treatment. The clinical parameters, such as plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment level (CAL), were also recorded at same time intervals. A correlation between the clinical parameters and endotoxin in GCF and peripheral blood was established in diseased cases as compared to healthy individuals. Results: Favorable clinical outcomes with the reduction of PI, GI, PPD, and CAL were achieved for Group A post-surgery when compared to baseline. The GCF endotoxin level in Group A was observed to be significantly higher than Group B and reduced favorably after treatment. In peripheral blood, there was no significant difference in endotoxin level between both the groups. Conclusion: It can be concluded from the results that the level of bacterial endotoxin was significantly raised in GCF, indicating its role in the causation of rapid destruction of the periodontium in aggressive periodontitis subjects.https://journals.lww.com/10.4103/jpbs.jpbs_1064_24aggressive periodontitisendotoxin levelsgingival crevicular fluid (gcf) |
| spellingShingle | Akanksha Kashyap Brijendra Singh Srishti Shankar Atul Gupta Piyush Gowrav Mohammad Arif Khan Measures of Bacterial Endotoxins in Gingival Crevicular Fluid and Peripheral Blood of Aggressive Periodontitis Cases—A Clinical Association Journal of Pharmacy and Bioallied Sciences aggressive periodontitis endotoxin levels gingival crevicular fluid (gcf) |
| title | Measures of Bacterial Endotoxins in Gingival Crevicular Fluid and Peripheral Blood of Aggressive Periodontitis Cases—A Clinical Association |
| title_full | Measures of Bacterial Endotoxins in Gingival Crevicular Fluid and Peripheral Blood of Aggressive Periodontitis Cases—A Clinical Association |
| title_fullStr | Measures of Bacterial Endotoxins in Gingival Crevicular Fluid and Peripheral Blood of Aggressive Periodontitis Cases—A Clinical Association |
| title_full_unstemmed | Measures of Bacterial Endotoxins in Gingival Crevicular Fluid and Peripheral Blood of Aggressive Periodontitis Cases—A Clinical Association |
| title_short | Measures of Bacterial Endotoxins in Gingival Crevicular Fluid and Peripheral Blood of Aggressive Periodontitis Cases—A Clinical Association |
| title_sort | measures of bacterial endotoxins in gingival crevicular fluid and peripheral blood of aggressive periodontitis cases a clinical association |
| topic | aggressive periodontitis endotoxin levels gingival crevicular fluid (gcf) |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1064_24 |
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