Impact of PEGylation and hyaluronan functionalization on lipoplex-mediated mRNA delivery to the canine retina

Impact of PEGylation and hyaluronan functionalization on lipoplex-mediated mRNA delivery to the canine retina

Efficient messenger ribonucleic acid (mRNA) delivery to the retina remains challenging. This study investigated the effects of various polyethylene glycol (PEG) derivatives on the stability and uptake of cationic lipid-based mRNA lipoplexes in vitro and assessed the delivery of selected formulations...

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Bibliographic Details
Main Authors: Tatyana Appelbaum, David A. Smith, Kei Takahashi, Jennifer C. Kwok, Hannah Sorenson, William A. Beltran
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Drug Delivery
Subjects:
Non-viral vectors
mRNA lipoplexes
PEGylation
stability
retinal mRNA delivery
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2025.2544688
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https://www.tandfonline.com/doi/10.1080/10717544.2025.2544688

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