A combination of clinical, electrocardiographic, and echocardiographic parameters predicts pulmonary hypertension occurrence in patients with end-stage renal disease
BackgroundPulmonary hypertension (PH) in patients with end-stage renal disease (ESRD) has a high incidence rate and mortality and its early identification is critical. However, whether a combination of clinical, electrocardiographic, and echocardiographic parameters can predict the occurrence of PH...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1337243/full |
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| author | Handong Ding Handong Ding Handong Ding Fei Zhang Fei Zhang Fei Zhang Jinbiao Zhong Jinbiao Zhong Jinbiao Zhong Jiashan Pan Jiashan Pan Jiashan Pan Yiding Chen Yiding Chen Yiding Chen Ji Zhang Ji Zhang Ji Zhang Qin Wang Guiyi Liao Guiyi Liao Guiyi Liao Zongyao Hao Zongyao Hao Zongyao Hao |
| author_facet | Handong Ding Handong Ding Handong Ding Fei Zhang Fei Zhang Fei Zhang Jinbiao Zhong Jinbiao Zhong Jinbiao Zhong Jiashan Pan Jiashan Pan Jiashan Pan Yiding Chen Yiding Chen Yiding Chen Ji Zhang Ji Zhang Ji Zhang Qin Wang Guiyi Liao Guiyi Liao Guiyi Liao Zongyao Hao Zongyao Hao Zongyao Hao |
| author_sort | Handong Ding |
| collection | DOAJ |
| description | BackgroundPulmonary hypertension (PH) in patients with end-stage renal disease (ESRD) has a high incidence rate and mortality and its early identification is critical. However, whether a combination of clinical, electrocardiographic, and echocardiographic parameters can predict the occurrence of PH in patients with ESRD remains to be elucidated. Herein, we evaluated the predictive value of the combined score of these parameters.MethodsData from 370 patients with newly diagnosed ESRD who underwent routine echocardiography and electrocardiography between May 2016 and May 2017 were retrospectively evaluated. The incidence of PH during a 60-month follow-up period was investigated. Twenty-one patients were excluded due to incomplete data among other reasons. Finally, 349 patients were included in the analysis, of whom, 158 (45%) developed PH.ResultsAnalysis of electrocardiogram reports suggested that a corrected Q-T interval (QTc) of >438.5 ms was associated with PH. Echocardiographic reports suggest that left atrial diameter (LAD), interventricular septum thickness in end-diastole (IVSd), stroke volume (SV), and pericardial effusion are also associated with PH development. Results of multivariate Cox analysis showed that LAD >3.785 cm, IVSd >1.165 cm, SV >79.5 ml, QTc >438.5 ms, and pericardial effusion were independent predictors of PH in patients with ESRD. The incidence of new-onset PH increased significantly with increasing composite scores, that is, the sum of risk scores determined using hazard ratios.ConclusionsA total score that includes a combination of parameters such as LAD >3.785 cm, IVSd>1.165 cm, SV >79.5 ml, QTc >438.5 ms, and pericardial effusion can help describe the risk of new-onset PH. |
| format | Article |
| id | doaj-art-f50f1a45e7104aad97c7303325cffd8c |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-f50f1a45e7104aad97c7303325cffd8c2025-01-10T14:38:15ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-11-011110.3389/fcvm.2024.13372431337243A combination of clinical, electrocardiographic, and echocardiographic parameters predicts pulmonary hypertension occurrence in patients with end-stage renal diseaseHandong Ding0Handong Ding1Handong Ding2Fei Zhang3Fei Zhang4Fei Zhang5Jinbiao Zhong6Jinbiao Zhong7Jinbiao Zhong8Jiashan Pan9Jiashan Pan10Jiashan Pan11Yiding Chen12Yiding Chen13Yiding Chen14Ji Zhang15Ji Zhang16Ji Zhang17Qin Wang18Guiyi Liao19Guiyi Liao20Guiyi Liao21Zongyao Hao22Zongyao Hao23Zongyao Hao24Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaInstitute of Urology, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaInstitute of Urology, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaInstitute of Urology, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaInstitute of Urology, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaInstitute of Urology, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaInstitute of Urology, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, ChinaPharmacy Department, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaInstitute of Urology, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, ChinaDepartment of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaInstitute of Urology, Anhui Medical University, Hefei, ChinaAnhui Province Key Laboratory of Urological and Andrological Diseases Research and Medical Transformation, Hefei, ChinaBackgroundPulmonary hypertension (PH) in patients with end-stage renal disease (ESRD) has a high incidence rate and mortality and its early identification is critical. However, whether a combination of clinical, electrocardiographic, and echocardiographic parameters can predict the occurrence of PH in patients with ESRD remains to be elucidated. Herein, we evaluated the predictive value of the combined score of these parameters.MethodsData from 370 patients with newly diagnosed ESRD who underwent routine echocardiography and electrocardiography between May 2016 and May 2017 were retrospectively evaluated. The incidence of PH during a 60-month follow-up period was investigated. Twenty-one patients were excluded due to incomplete data among other reasons. Finally, 349 patients were included in the analysis, of whom, 158 (45%) developed PH.ResultsAnalysis of electrocardiogram reports suggested that a corrected Q-T interval (QTc) of >438.5 ms was associated with PH. Echocardiographic reports suggest that left atrial diameter (LAD), interventricular septum thickness in end-diastole (IVSd), stroke volume (SV), and pericardial effusion are also associated with PH development. Results of multivariate Cox analysis showed that LAD >3.785 cm, IVSd >1.165 cm, SV >79.5 ml, QTc >438.5 ms, and pericardial effusion were independent predictors of PH in patients with ESRD. The incidence of new-onset PH increased significantly with increasing composite scores, that is, the sum of risk scores determined using hazard ratios.ConclusionsA total score that includes a combination of parameters such as LAD >3.785 cm, IVSd>1.165 cm, SV >79.5 ml, QTc >438.5 ms, and pericardial effusion can help describe the risk of new-onset PH.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1337243/fullelectrocardiographyechocardiographypericardial effusionpulmonary hypertensionend-stage renal disease |
| spellingShingle | Handong Ding Handong Ding Handong Ding Fei Zhang Fei Zhang Fei Zhang Jinbiao Zhong Jinbiao Zhong Jinbiao Zhong Jiashan Pan Jiashan Pan Jiashan Pan Yiding Chen Yiding Chen Yiding Chen Ji Zhang Ji Zhang Ji Zhang Qin Wang Guiyi Liao Guiyi Liao Guiyi Liao Zongyao Hao Zongyao Hao Zongyao Hao A combination of clinical, electrocardiographic, and echocardiographic parameters predicts pulmonary hypertension occurrence in patients with end-stage renal disease Frontiers in Cardiovascular Medicine electrocardiography echocardiography pericardial effusion pulmonary hypertension end-stage renal disease |
| title | A combination of clinical, electrocardiographic, and echocardiographic parameters predicts pulmonary hypertension occurrence in patients with end-stage renal disease |
| title_full | A combination of clinical, electrocardiographic, and echocardiographic parameters predicts pulmonary hypertension occurrence in patients with end-stage renal disease |
| title_fullStr | A combination of clinical, electrocardiographic, and echocardiographic parameters predicts pulmonary hypertension occurrence in patients with end-stage renal disease |
| title_full_unstemmed | A combination of clinical, electrocardiographic, and echocardiographic parameters predicts pulmonary hypertension occurrence in patients with end-stage renal disease |
| title_short | A combination of clinical, electrocardiographic, and echocardiographic parameters predicts pulmonary hypertension occurrence in patients with end-stage renal disease |
| title_sort | combination of clinical electrocardiographic and echocardiographic parameters predicts pulmonary hypertension occurrence in patients with end stage renal disease |
| topic | electrocardiography echocardiography pericardial effusion pulmonary hypertension end-stage renal disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1337243/full |
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